Cargando…
Alkyl-Resorcinol Derivatives as Inhibitors of GDP-Mannose Pyrophosphorylase with Antileishmanial Activities
Leishmaniasis is a vector-borne disease caused by the protozoan parasite Leishmania found in tropical and sub-tropical areas, affecting 12 million people around the world. Only few treatments are available against this disease and all of them present issues of toxicity and/or resistance. In this con...
Autores principales: | Levaique, Hélène, Pamlard, Olivier, Apel, Cécile, Bignon, Jérôme, Arriola, Margaux, Kuhner, Robin, Awang, Khalijah, Loiseau, Philippe M., Litaudon, Marc, Pomel, Sébastien |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999366/ https://www.ncbi.nlm.nih.gov/pubmed/33799883 http://dx.doi.org/10.3390/molecules26061551 |
Ejemplares similares
-
GDP-Mannose Pyrophosphorylase: A Biologically Validated Target for Drug Development Against Leishmaniasis
por: Pomel, Sébastien, et al.
Publicado: (2019) -
Biochemical analysis of leishmanial and human GDP-Mannose Pyrophosphorylases and selection of inhibitors as new leads
por: Mao, Wei, et al.
Publicado: (2017) -
Minor Impact of A258D Mutation on Biochemical and Enzymatic Properties of Leishmania infantum GDP-Mannose Pyrophosphorylase
por: Mao, Wei, et al.
Publicado: (2022) -
GDP-Mannose Pyrophosphorylase B (GMPPB)-Related Disorders
por: Chompoopong, Pitcha, et al.
Publicado: (2023) -
Structural insights into selective inhibition of leishmanial GDP-mannose pyrophosphorylase
por: Li, Hang, et al.
Publicado: (2022)