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Prevalence of Prostate Cancer at Different Clinical Stages in Italy: Estimated Burden of Disease Based on a Modelling Study

SIMPLE SUMMARY: The burden of prostate cancer is particularly high in Italy, where the disease ranks 4th among incident cancers overall and is 1st in men. In order to adequately plan health services and targeted interventions for the management of this neoplasm in Italy, it is of utmost importance t...

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Detalles Bibliográficos
Autores principales: Spandonaro, Federico, D’Angela, Daniela, Polistena, Barbara, Bruzzi, Paolo, Iacovelli, Roberto, Luccarini, Irene, Stagni, Paola, Brigido, Alessia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999492/
https://www.ncbi.nlm.nih.gov/pubmed/33801914
http://dx.doi.org/10.3390/biology10030210
Descripción
Sumario:SIMPLE SUMMARY: The burden of prostate cancer is particularly high in Italy, where the disease ranks 4th among incident cancers overall and is 1st in men. In order to adequately plan health services and targeted interventions for the management of this neoplasm in Italy, it is of utmost importance to have a clear picture of the current number of patients surviving prostate cancer and of their needs in terms of cancer care. In our research, we aim therefore to quantify alive prostate cancer patients in Italy, and to provide relevant information on the number of survivors at different clinical stages of disease. ABSTRACT: Understanding the distribution of prostate cancer (PC) at various clinical stages of disease is of utmost importance to quantify the cancer care needs of patients and to adequately plan health services. The aim of this analysis is thus to provide a model-based estimation of the number of prevalent PC patients at different clinical stages in the Italian setting. A simulation model of patient transitions was constructed on a yearly basis using data obtained through a literature review on the incidence, prevalence, progression and mortality of PC, with specific focus on disease stage. A total of 462,570 prevalent PC patients were estimated at 1 January 2019. According to the model, 94.8% of them had non-metastatic PC and 5.2% had metastatic disease. Among the non-metastatic patients, most had T1/T2 PC (85.6%), followed by T3/T4 (10.9%) and T0/Tx PC (3.6%). About 20% of the T3/T4 patients had biochemically recurrent PC. Among the metastatic PC patients, 66.1% had castration-resistant PC and 33.9% had hormone-sensitive PC. This study provided original information on the distribution of PC according to different clinical stages that may be useful to define strategies, understand the PC disease pathway, estimate treatment-related needs and, possibly, plan targeted interventions for public health management of prostate cancer in Italy.