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Editorial of Special Issue “Regulatory Roles of Inflammasomes in Human Diseases”

Inflammation is an innate immunity protecting the body from pathogens and cellular damages and comprises two steps; 1) priming (preparatory step) and triggering (activation step). The key feature of the triggering step is the activation of inflammasomes that are intracellular protein complexes consi...

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Autores principales: Yi, Young-Su, Yun, Miyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999501/
https://www.ncbi.nlm.nih.gov/pubmed/33809447
http://dx.doi.org/10.3390/ijms22063008
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author Yi, Young-Su
Yun, Miyong
author_facet Yi, Young-Su
Yun, Miyong
author_sort Yi, Young-Su
collection PubMed
description Inflammation is an innate immunity protecting the body from pathogens and cellular damages and comprises two steps; 1) priming (preparatory step) and triggering (activation step). The key feature of the triggering step is the activation of inflammasomes that are intracellular protein complexes consisting of pattern recognition receptors and inflammatory molecules. Inflammasomes are activated in response to various ligands, leading to the caspase-1-mediated maturation and secretion of pro-inflammatory cytokines, IL-1β and IL-18 and the gasdermin D-mediated pyroptosis, an inflammatory form of cell death. Previous studies have demonstrated that inflammasome activation is a key determinant of inflammatory responses and many human diseases; therefore, inflammasomes have been attracted much attention as critical drug targets to prevent and treat various human diseases.
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spelling pubmed-79995012021-03-28 Editorial of Special Issue “Regulatory Roles of Inflammasomes in Human Diseases” Yi, Young-Su Yun, Miyong Int J Mol Sci Editorial Inflammation is an innate immunity protecting the body from pathogens and cellular damages and comprises two steps; 1) priming (preparatory step) and triggering (activation step). The key feature of the triggering step is the activation of inflammasomes that are intracellular protein complexes consisting of pattern recognition receptors and inflammatory molecules. Inflammasomes are activated in response to various ligands, leading to the caspase-1-mediated maturation and secretion of pro-inflammatory cytokines, IL-1β and IL-18 and the gasdermin D-mediated pyroptosis, an inflammatory form of cell death. Previous studies have demonstrated that inflammasome activation is a key determinant of inflammatory responses and many human diseases; therefore, inflammasomes have been attracted much attention as critical drug targets to prevent and treat various human diseases. MDPI 2021-03-16 /pmc/articles/PMC7999501/ /pubmed/33809447 http://dx.doi.org/10.3390/ijms22063008 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Editorial
Yi, Young-Su
Yun, Miyong
Editorial of Special Issue “Regulatory Roles of Inflammasomes in Human Diseases”
title Editorial of Special Issue “Regulatory Roles of Inflammasomes in Human Diseases”
title_full Editorial of Special Issue “Regulatory Roles of Inflammasomes in Human Diseases”
title_fullStr Editorial of Special Issue “Regulatory Roles of Inflammasomes in Human Diseases”
title_full_unstemmed Editorial of Special Issue “Regulatory Roles of Inflammasomes in Human Diseases”
title_short Editorial of Special Issue “Regulatory Roles of Inflammasomes in Human Diseases”
title_sort editorial of special issue “regulatory roles of inflammasomes in human diseases”
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999501/
https://www.ncbi.nlm.nih.gov/pubmed/33809447
http://dx.doi.org/10.3390/ijms22063008
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