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Editorial of Special Issue “Regulatory Roles of Inflammasomes in Human Diseases”
Inflammation is an innate immunity protecting the body from pathogens and cellular damages and comprises two steps; 1) priming (preparatory step) and triggering (activation step). The key feature of the triggering step is the activation of inflammasomes that are intracellular protein complexes consi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999501/ https://www.ncbi.nlm.nih.gov/pubmed/33809447 http://dx.doi.org/10.3390/ijms22063008 |
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author | Yi, Young-Su Yun, Miyong |
author_facet | Yi, Young-Su Yun, Miyong |
author_sort | Yi, Young-Su |
collection | PubMed |
description | Inflammation is an innate immunity protecting the body from pathogens and cellular damages and comprises two steps; 1) priming (preparatory step) and triggering (activation step). The key feature of the triggering step is the activation of inflammasomes that are intracellular protein complexes consisting of pattern recognition receptors and inflammatory molecules. Inflammasomes are activated in response to various ligands, leading to the caspase-1-mediated maturation and secretion of pro-inflammatory cytokines, IL-1β and IL-18 and the gasdermin D-mediated pyroptosis, an inflammatory form of cell death. Previous studies have demonstrated that inflammasome activation is a key determinant of inflammatory responses and many human diseases; therefore, inflammasomes have been attracted much attention as critical drug targets to prevent and treat various human diseases. |
format | Online Article Text |
id | pubmed-7999501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79995012021-03-28 Editorial of Special Issue “Regulatory Roles of Inflammasomes in Human Diseases” Yi, Young-Su Yun, Miyong Int J Mol Sci Editorial Inflammation is an innate immunity protecting the body from pathogens and cellular damages and comprises two steps; 1) priming (preparatory step) and triggering (activation step). The key feature of the triggering step is the activation of inflammasomes that are intracellular protein complexes consisting of pattern recognition receptors and inflammatory molecules. Inflammasomes are activated in response to various ligands, leading to the caspase-1-mediated maturation and secretion of pro-inflammatory cytokines, IL-1β and IL-18 and the gasdermin D-mediated pyroptosis, an inflammatory form of cell death. Previous studies have demonstrated that inflammasome activation is a key determinant of inflammatory responses and many human diseases; therefore, inflammasomes have been attracted much attention as critical drug targets to prevent and treat various human diseases. MDPI 2021-03-16 /pmc/articles/PMC7999501/ /pubmed/33809447 http://dx.doi.org/10.3390/ijms22063008 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Editorial Yi, Young-Su Yun, Miyong Editorial of Special Issue “Regulatory Roles of Inflammasomes in Human Diseases” |
title | Editorial of Special Issue “Regulatory Roles of Inflammasomes in Human Diseases” |
title_full | Editorial of Special Issue “Regulatory Roles of Inflammasomes in Human Diseases” |
title_fullStr | Editorial of Special Issue “Regulatory Roles of Inflammasomes in Human Diseases” |
title_full_unstemmed | Editorial of Special Issue “Regulatory Roles of Inflammasomes in Human Diseases” |
title_short | Editorial of Special Issue “Regulatory Roles of Inflammasomes in Human Diseases” |
title_sort | editorial of special issue “regulatory roles of inflammasomes in human diseases” |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999501/ https://www.ncbi.nlm.nih.gov/pubmed/33809447 http://dx.doi.org/10.3390/ijms22063008 |
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