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COVID-19 Rapid Antigen Test as Screening Strategy at Points of Entry: Experience in Lazio Region, Central Italy, August–October 2020
COVID-19 pandemic is a dramatic health, social and economic global challenge. There is urgent need to maximize testing capacity. Rapid Antigen Tests (RAT) represent good candidates for point-of-care and mass surveillance testing to rapidly identify SARS-CoV-2-infected people, counterbalancing lower...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999510/ https://www.ncbi.nlm.nih.gov/pubmed/33805832 http://dx.doi.org/10.3390/biom11030425 |
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author | Colavita, Francesca Vairo, Francesco Meschi, Silvia Valli, Maria Beatrice Lalle, Eleonora Castilletti, Concetta Fusco, Danilo Spiga, Giuseppe Bartoletti, Pierluigi Ursino, Simona Sanguinetti, Maurizio Di Caro, Antonino Vaia, Francesco Ippolito, Giuseppe Capobianchi, Maria Rosaria |
author_facet | Colavita, Francesca Vairo, Francesco Meschi, Silvia Valli, Maria Beatrice Lalle, Eleonora Castilletti, Concetta Fusco, Danilo Spiga, Giuseppe Bartoletti, Pierluigi Ursino, Simona Sanguinetti, Maurizio Di Caro, Antonino Vaia, Francesco Ippolito, Giuseppe Capobianchi, Maria Rosaria |
author_sort | Colavita, Francesca |
collection | PubMed |
description | COVID-19 pandemic is a dramatic health, social and economic global challenge. There is urgent need to maximize testing capacity. Rapid Antigen Tests (RAT) represent good candidates for point-of-care and mass surveillance testing to rapidly identify SARS-CoV-2-infected people, counterbalancing lower sensitivity vs. gold standard molecular tests with fast results and possible recurrent testing. We describe the results obtained with the testing algorithm implemented at points of entry (airports and ports) in the Lazio Region (Italy), using the STANDARD F COVID-19 Antigen Fluorescence ImmunoAssay (FIA), followed by molecular confirmation of FIA-positive samples. From mid-August to mid-October 2020, 73,643 RAT were reported to the Regional Surveillance Information System for travelers at points of entry in Lazio Region. Of these, 1176 (1.6%) were FIA-positive, and the proportion of RT-PCR-confirmed samples was 40.5%. Our data show that the probability of confirmation was directly dependent from the semi-quantitative FIA results. In addition, the molecularly confirmed samples were those with high levels of virus and that were actually harboring infectious virus. These results support public health strategies based on early mass screening campaigns by RAT in settings where molecular testing is not feasible or easily accessible, such as points of entry. This approach would contribute to promptly controlling viral spread through travel, which is now of particular concern due to the spread of SARS-CoV-2 variants. |
format | Online Article Text |
id | pubmed-7999510 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79995102021-03-28 COVID-19 Rapid Antigen Test as Screening Strategy at Points of Entry: Experience in Lazio Region, Central Italy, August–October 2020 Colavita, Francesca Vairo, Francesco Meschi, Silvia Valli, Maria Beatrice Lalle, Eleonora Castilletti, Concetta Fusco, Danilo Spiga, Giuseppe Bartoletti, Pierluigi Ursino, Simona Sanguinetti, Maurizio Di Caro, Antonino Vaia, Francesco Ippolito, Giuseppe Capobianchi, Maria Rosaria Biomolecules Article COVID-19 pandemic is a dramatic health, social and economic global challenge. There is urgent need to maximize testing capacity. Rapid Antigen Tests (RAT) represent good candidates for point-of-care and mass surveillance testing to rapidly identify SARS-CoV-2-infected people, counterbalancing lower sensitivity vs. gold standard molecular tests with fast results and possible recurrent testing. We describe the results obtained with the testing algorithm implemented at points of entry (airports and ports) in the Lazio Region (Italy), using the STANDARD F COVID-19 Antigen Fluorescence ImmunoAssay (FIA), followed by molecular confirmation of FIA-positive samples. From mid-August to mid-October 2020, 73,643 RAT were reported to the Regional Surveillance Information System for travelers at points of entry in Lazio Region. Of these, 1176 (1.6%) were FIA-positive, and the proportion of RT-PCR-confirmed samples was 40.5%. Our data show that the probability of confirmation was directly dependent from the semi-quantitative FIA results. In addition, the molecularly confirmed samples were those with high levels of virus and that were actually harboring infectious virus. These results support public health strategies based on early mass screening campaigns by RAT in settings where molecular testing is not feasible or easily accessible, such as points of entry. This approach would contribute to promptly controlling viral spread through travel, which is now of particular concern due to the spread of SARS-CoV-2 variants. MDPI 2021-03-13 /pmc/articles/PMC7999510/ /pubmed/33805832 http://dx.doi.org/10.3390/biom11030425 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Colavita, Francesca Vairo, Francesco Meschi, Silvia Valli, Maria Beatrice Lalle, Eleonora Castilletti, Concetta Fusco, Danilo Spiga, Giuseppe Bartoletti, Pierluigi Ursino, Simona Sanguinetti, Maurizio Di Caro, Antonino Vaia, Francesco Ippolito, Giuseppe Capobianchi, Maria Rosaria COVID-19 Rapid Antigen Test as Screening Strategy at Points of Entry: Experience in Lazio Region, Central Italy, August–October 2020 |
title | COVID-19 Rapid Antigen Test as Screening Strategy at Points of Entry: Experience in Lazio Region, Central Italy, August–October 2020 |
title_full | COVID-19 Rapid Antigen Test as Screening Strategy at Points of Entry: Experience in Lazio Region, Central Italy, August–October 2020 |
title_fullStr | COVID-19 Rapid Antigen Test as Screening Strategy at Points of Entry: Experience in Lazio Region, Central Italy, August–October 2020 |
title_full_unstemmed | COVID-19 Rapid Antigen Test as Screening Strategy at Points of Entry: Experience in Lazio Region, Central Italy, August–October 2020 |
title_short | COVID-19 Rapid Antigen Test as Screening Strategy at Points of Entry: Experience in Lazio Region, Central Italy, August–October 2020 |
title_sort | covid-19 rapid antigen test as screening strategy at points of entry: experience in lazio region, central italy, august–october 2020 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999510/ https://www.ncbi.nlm.nih.gov/pubmed/33805832 http://dx.doi.org/10.3390/biom11030425 |
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