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Oxidative Stress and Vascular Damage in the Context of Obesity: The Hidden Guest

The vascular system plays a central role in the transport of cells, oxygen and nutrients between different regions of the body, depending on the needs, as well as of metabolic waste products for their elimination. While the structure of different components of the vascular system varies, these struc...

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Autores principales: Martínez-Martínez, Ernesto, V. Souza-Neto, Francisco, Jiménez-González, Sara, Cachofeiro, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999611/
https://www.ncbi.nlm.nih.gov/pubmed/33800427
http://dx.doi.org/10.3390/antiox10030406
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author Martínez-Martínez, Ernesto
V. Souza-Neto, Francisco
Jiménez-González, Sara
Cachofeiro, Victoria
author_facet Martínez-Martínez, Ernesto
V. Souza-Neto, Francisco
Jiménez-González, Sara
Cachofeiro, Victoria
author_sort Martínez-Martínez, Ernesto
collection PubMed
description The vascular system plays a central role in the transport of cells, oxygen and nutrients between different regions of the body, depending on the needs, as well as of metabolic waste products for their elimination. While the structure of different components of the vascular system varies, these structures, especially those of main arteries and arterioles, can be affected by the presence of different cardiovascular risk factors, including obesity. This vascular remodeling is mainly characterized by a thickening of the media layer as a consequence of changes in smooth muscle cells or excessive fibrosis accumulation. These vascular changes associated with obesity can trigger functional alterations, with endothelial dysfunction and vascular stiffness being especially common features of obese vessels. These changes can also lead to impaired tissue perfusion that may affect multiple tissues and organs. In this review, we focus on the role played by perivascular adipose tissue, the activation of the renin-angiotensin-aldosterone system and endoplasmic reticulum stress in the vascular dysfunction associated with obesity. In addition, the participation of oxidative stress in this vascular damage, which can be produced in the perivascular adipose tissue as well as in other components of the vascular wall, is updated.
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spelling pubmed-79996112021-03-28 Oxidative Stress and Vascular Damage in the Context of Obesity: The Hidden Guest Martínez-Martínez, Ernesto V. Souza-Neto, Francisco Jiménez-González, Sara Cachofeiro, Victoria Antioxidants (Basel) Review The vascular system plays a central role in the transport of cells, oxygen and nutrients between different regions of the body, depending on the needs, as well as of metabolic waste products for their elimination. While the structure of different components of the vascular system varies, these structures, especially those of main arteries and arterioles, can be affected by the presence of different cardiovascular risk factors, including obesity. This vascular remodeling is mainly characterized by a thickening of the media layer as a consequence of changes in smooth muscle cells or excessive fibrosis accumulation. These vascular changes associated with obesity can trigger functional alterations, with endothelial dysfunction and vascular stiffness being especially common features of obese vessels. These changes can also lead to impaired tissue perfusion that may affect multiple tissues and organs. In this review, we focus on the role played by perivascular adipose tissue, the activation of the renin-angiotensin-aldosterone system and endoplasmic reticulum stress in the vascular dysfunction associated with obesity. In addition, the participation of oxidative stress in this vascular damage, which can be produced in the perivascular adipose tissue as well as in other components of the vascular wall, is updated. MDPI 2021-03-08 /pmc/articles/PMC7999611/ /pubmed/33800427 http://dx.doi.org/10.3390/antiox10030406 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Martínez-Martínez, Ernesto
V. Souza-Neto, Francisco
Jiménez-González, Sara
Cachofeiro, Victoria
Oxidative Stress and Vascular Damage in the Context of Obesity: The Hidden Guest
title Oxidative Stress and Vascular Damage in the Context of Obesity: The Hidden Guest
title_full Oxidative Stress and Vascular Damage in the Context of Obesity: The Hidden Guest
title_fullStr Oxidative Stress and Vascular Damage in the Context of Obesity: The Hidden Guest
title_full_unstemmed Oxidative Stress and Vascular Damage in the Context of Obesity: The Hidden Guest
title_short Oxidative Stress and Vascular Damage in the Context of Obesity: The Hidden Guest
title_sort oxidative stress and vascular damage in the context of obesity: the hidden guest
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999611/
https://www.ncbi.nlm.nih.gov/pubmed/33800427
http://dx.doi.org/10.3390/antiox10030406
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