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SLCO1B1 Phenotype and CYP3A5 Polymorphism Significantly Affect Atorvastatin Bioavailability
Atorvastatin, prescribed for the treatment of hypercholesterolemia, demonstrated overwhelming benefits in reducing cardiovascular morbidity and mortality. However, many patients discontinue therapy due to adverse reactions, especially myopathy. The Dutch Pharmacogenetics Working Group (DPWG) recomme...
Autores principales: | Zubiaur, Pablo, Benedicto, Maria Dolores, Villapalos-García, Gonzalo, Navares-Gómez, Marcos, Mejía-Abril, Gina, Román, Manuel, Martín-Vílchez, Samuel, Ochoa, Dolores, Abad-Santos, Francisco |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999651/ https://www.ncbi.nlm.nih.gov/pubmed/33805706 http://dx.doi.org/10.3390/jpm11030204 |
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