Cargando…

Oral Symptoms Associated with COVID-19 and Their Pathogenic Mechanisms: A Literature Review

Since the worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, management of coronavirus disease 2019 (COVID-19) has been challenging for healthcare providers. The oral cavity is referred to as a target of SARS-CoV-2. The aim of this study was to review oral sy...

Descripción completa

Detalles Bibliográficos
Autor principal: Tsuchiya, Hironori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999671/
https://www.ncbi.nlm.nih.gov/pubmed/33799583
http://dx.doi.org/10.3390/dj9030032
_version_ 1783670835126468608
author Tsuchiya, Hironori
author_facet Tsuchiya, Hironori
author_sort Tsuchiya, Hironori
collection PubMed
description Since the worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, management of coronavirus disease 2019 (COVID-19) has been challenging for healthcare providers. The oral cavity is referred to as a target of SARS-CoV-2. The aim of this study was to review oral symptoms specific to COVID-19 patients from the point of view of symptom prevalence and pathogenesis and to speculate the pathogenic mechanisms underlying them. Scientific articles were retrieved by searching PubMed/MEDLINE, Google Scholar, medRxiv, and bioRxiv from 3 February 2020 to 31 December 2020, and they were reviewed by title, abstract, and text for relevance. The literature search indicated that COVID-19 patients frequently present with gustatory dysfunction, xerostomia, and oral mucosal lesions, while their prevalence is likely to vary by country, age, gender, and disease severity. Gustatory dysfunction and xerostomia appear at an early stage of SARS-CoV-2 infection and last relatively long. One of possible pathogenic mechanisms of both symptoms is attributed to the expression of viral cellular entry-relevant receptors in taste cells and salivary glands. Dental professionals who can first become aware of oral symptoms associated with COVID-19 will play a more active role in and make a greater contribution to diagnosis and prevention of COVID-19.
format Online
Article
Text
id pubmed-7999671
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79996712021-03-28 Oral Symptoms Associated with COVID-19 and Their Pathogenic Mechanisms: A Literature Review Tsuchiya, Hironori Dent J (Basel) Review Since the worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, management of coronavirus disease 2019 (COVID-19) has been challenging for healthcare providers. The oral cavity is referred to as a target of SARS-CoV-2. The aim of this study was to review oral symptoms specific to COVID-19 patients from the point of view of symptom prevalence and pathogenesis and to speculate the pathogenic mechanisms underlying them. Scientific articles were retrieved by searching PubMed/MEDLINE, Google Scholar, medRxiv, and bioRxiv from 3 February 2020 to 31 December 2020, and they were reviewed by title, abstract, and text for relevance. The literature search indicated that COVID-19 patients frequently present with gustatory dysfunction, xerostomia, and oral mucosal lesions, while their prevalence is likely to vary by country, age, gender, and disease severity. Gustatory dysfunction and xerostomia appear at an early stage of SARS-CoV-2 infection and last relatively long. One of possible pathogenic mechanisms of both symptoms is attributed to the expression of viral cellular entry-relevant receptors in taste cells and salivary glands. Dental professionals who can first become aware of oral symptoms associated with COVID-19 will play a more active role in and make a greater contribution to diagnosis and prevention of COVID-19. MDPI 2021-03-11 /pmc/articles/PMC7999671/ /pubmed/33799583 http://dx.doi.org/10.3390/dj9030032 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Tsuchiya, Hironori
Oral Symptoms Associated with COVID-19 and Their Pathogenic Mechanisms: A Literature Review
title Oral Symptoms Associated with COVID-19 and Their Pathogenic Mechanisms: A Literature Review
title_full Oral Symptoms Associated with COVID-19 and Their Pathogenic Mechanisms: A Literature Review
title_fullStr Oral Symptoms Associated with COVID-19 and Their Pathogenic Mechanisms: A Literature Review
title_full_unstemmed Oral Symptoms Associated with COVID-19 and Their Pathogenic Mechanisms: A Literature Review
title_short Oral Symptoms Associated with COVID-19 and Their Pathogenic Mechanisms: A Literature Review
title_sort oral symptoms associated with covid-19 and their pathogenic mechanisms: a literature review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999671/
https://www.ncbi.nlm.nih.gov/pubmed/33799583
http://dx.doi.org/10.3390/dj9030032
work_keys_str_mv AT tsuchiyahironori oralsymptomsassociatedwithcovid19andtheirpathogenicmechanismsaliteraturereview