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Comparing Levels of Metabolic Predictors of Coronary Heart Disease between Healthy Lean and Overweight Females
Screening for the metabolomic signature of coronary heart disease (CHD) before disease onset could help in early diagnosis and potentially disease prevention. In this study, the levels of 17 CHD metabolic biomarkers in apparently healthy overweight females were compared to lean counterparts, and the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999722/ https://www.ncbi.nlm.nih.gov/pubmed/33804097 http://dx.doi.org/10.3390/metabo11030169 |
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author | Abu-El-Ruz, Rasha Abdel-Rahman, Manar E. Atkin, Stephen L. Elrayess, Mohamed A. |
author_facet | Abu-El-Ruz, Rasha Abdel-Rahman, Manar E. Atkin, Stephen L. Elrayess, Mohamed A. |
author_sort | Abu-El-Ruz, Rasha |
collection | PubMed |
description | Screening for the metabolomic signature of coronary heart disease (CHD) before disease onset could help in early diagnosis and potentially disease prevention. In this study, the levels of 17 CHD metabolic biomarkers in apparently healthy overweight females were compared to lean counterparts, and their associations with conventional clinical risk factors were determined. Clinical and metabolic data from 200 apparently healthy non-obese Qatari females were collected from Qatar Biobank (discovery cohort). Logistic regression was used to assess the association between body mass index (BMI) groups and 17 CHD metabolic biomarkers, and receiver operating characteristic (ROC) analysis was used to evaluate the prognostic value of CHD metabolic biomarkers in overweight. Stepwise linear regression was performed to identify the classical risk factors associated with CHD metabolites differentiating the two BMI groups. Validation of the association of CHD metabolic biomarkers with BMI groups was performed in 107 subjects (replication cohort). Out of the tested CHD metabolic biomarkers, five were significantly different between lean and overweight females in the discovery cohort (AUC = 0.73). Among these, the association of mannose, asparagine, and linoleate with BMI groups was confirmed in the replication cohort (AUC = 0.97). Significant correlations between predictors of CHD in overweight healthy women and classical risk factors were observed, including serum levels of cholesterol, testosterone, triiodothyronine, thyroxine, creatinine, albumin, bilirubin, glucose, c-peptide, uric acid, calcium and chloride. Apparently, healthy overweight females exhibit significantly different levels of specific CHD metabolites compared to their lean counterparts, offering a prognostic potential with preventative value. |
format | Online Article Text |
id | pubmed-7999722 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79997222021-03-28 Comparing Levels of Metabolic Predictors of Coronary Heart Disease between Healthy Lean and Overweight Females Abu-El-Ruz, Rasha Abdel-Rahman, Manar E. Atkin, Stephen L. Elrayess, Mohamed A. Metabolites Article Screening for the metabolomic signature of coronary heart disease (CHD) before disease onset could help in early diagnosis and potentially disease prevention. In this study, the levels of 17 CHD metabolic biomarkers in apparently healthy overweight females were compared to lean counterparts, and their associations with conventional clinical risk factors were determined. Clinical and metabolic data from 200 apparently healthy non-obese Qatari females were collected from Qatar Biobank (discovery cohort). Logistic regression was used to assess the association between body mass index (BMI) groups and 17 CHD metabolic biomarkers, and receiver operating characteristic (ROC) analysis was used to evaluate the prognostic value of CHD metabolic biomarkers in overweight. Stepwise linear regression was performed to identify the classical risk factors associated with CHD metabolites differentiating the two BMI groups. Validation of the association of CHD metabolic biomarkers with BMI groups was performed in 107 subjects (replication cohort). Out of the tested CHD metabolic biomarkers, five were significantly different between lean and overweight females in the discovery cohort (AUC = 0.73). Among these, the association of mannose, asparagine, and linoleate with BMI groups was confirmed in the replication cohort (AUC = 0.97). Significant correlations between predictors of CHD in overweight healthy women and classical risk factors were observed, including serum levels of cholesterol, testosterone, triiodothyronine, thyroxine, creatinine, albumin, bilirubin, glucose, c-peptide, uric acid, calcium and chloride. Apparently, healthy overweight females exhibit significantly different levels of specific CHD metabolites compared to their lean counterparts, offering a prognostic potential with preventative value. MDPI 2021-03-15 /pmc/articles/PMC7999722/ /pubmed/33804097 http://dx.doi.org/10.3390/metabo11030169 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Abu-El-Ruz, Rasha Abdel-Rahman, Manar E. Atkin, Stephen L. Elrayess, Mohamed A. Comparing Levels of Metabolic Predictors of Coronary Heart Disease between Healthy Lean and Overweight Females |
title | Comparing Levels of Metabolic Predictors of Coronary Heart Disease between Healthy Lean and Overweight Females |
title_full | Comparing Levels of Metabolic Predictors of Coronary Heart Disease between Healthy Lean and Overweight Females |
title_fullStr | Comparing Levels of Metabolic Predictors of Coronary Heart Disease between Healthy Lean and Overweight Females |
title_full_unstemmed | Comparing Levels of Metabolic Predictors of Coronary Heart Disease between Healthy Lean and Overweight Females |
title_short | Comparing Levels of Metabolic Predictors of Coronary Heart Disease between Healthy Lean and Overweight Females |
title_sort | comparing levels of metabolic predictors of coronary heart disease between healthy lean and overweight females |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999722/ https://www.ncbi.nlm.nih.gov/pubmed/33804097 http://dx.doi.org/10.3390/metabo11030169 |
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