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The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials
Many studies have shown that resveratrol has a lot of therapeutic effects on liver disorders. Its administration can significantly increase the survival rate after liver transplantation, reduce fat deposition and ischemia-induced necrosis and apoptosis in Wistar rats. Resveratrol can provide Liver p...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999728/ https://www.ncbi.nlm.nih.gov/pubmed/33805795 http://dx.doi.org/10.3390/nu13030933 |
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author | Izzo, Carmine Annunziata, Monica Melara, Giuseppe Sciorio, Roberta Dallio, Marcello Masarone, Mario Federico, Alessandro Persico, Marcello |
author_facet | Izzo, Carmine Annunziata, Monica Melara, Giuseppe Sciorio, Roberta Dallio, Marcello Masarone, Mario Federico, Alessandro Persico, Marcello |
author_sort | Izzo, Carmine |
collection | PubMed |
description | Many studies have shown that resveratrol has a lot of therapeutic effects on liver disorders. Its administration can significantly increase the survival rate after liver transplantation, reduce fat deposition and ischemia-induced necrosis and apoptosis in Wistar rats. Resveratrol can provide Liver protection against chemical, cholestatic, and alcohol-mediated damage. It can improve glucose metabolism and lipid profile, reduce liver fibrosis, and steatosis. Additionally, it is capable of altering the fatty acid composition of the liver cells. Resveratrol may be a potential treatment option for the management of non-alcoholic fatty liver disease (NAFLD) due to its anti-inflammatory, antioxidant, and calorie-restricting effects. There are also studies that have evaluated the effect of resveratrol on lipid and liver enzyme profiles among patients with metabolic syndrome (MetS) and related disorders. Based on the extent of liver disease worldwide and the need to find new treatment possibilities, this review critically examines current in vitro and in vivo preclinical studies and human clinical studies related to liver protection. |
format | Online Article Text |
id | pubmed-7999728 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79997282021-03-28 The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials Izzo, Carmine Annunziata, Monica Melara, Giuseppe Sciorio, Roberta Dallio, Marcello Masarone, Mario Federico, Alessandro Persico, Marcello Nutrients Review Many studies have shown that resveratrol has a lot of therapeutic effects on liver disorders. Its administration can significantly increase the survival rate after liver transplantation, reduce fat deposition and ischemia-induced necrosis and apoptosis in Wistar rats. Resveratrol can provide Liver protection against chemical, cholestatic, and alcohol-mediated damage. It can improve glucose metabolism and lipid profile, reduce liver fibrosis, and steatosis. Additionally, it is capable of altering the fatty acid composition of the liver cells. Resveratrol may be a potential treatment option for the management of non-alcoholic fatty liver disease (NAFLD) due to its anti-inflammatory, antioxidant, and calorie-restricting effects. There are also studies that have evaluated the effect of resveratrol on lipid and liver enzyme profiles among patients with metabolic syndrome (MetS) and related disorders. Based on the extent of liver disease worldwide and the need to find new treatment possibilities, this review critically examines current in vitro and in vivo preclinical studies and human clinical studies related to liver protection. MDPI 2021-03-13 /pmc/articles/PMC7999728/ /pubmed/33805795 http://dx.doi.org/10.3390/nu13030933 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Review Izzo, Carmine Annunziata, Monica Melara, Giuseppe Sciorio, Roberta Dallio, Marcello Masarone, Mario Federico, Alessandro Persico, Marcello The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials |
title | The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials |
title_full | The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials |
title_fullStr | The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials |
title_full_unstemmed | The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials |
title_short | The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials |
title_sort | role of resveratrol in liver disease: a comprehensive review from in vitro to clinical trials |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999728/ https://www.ncbi.nlm.nih.gov/pubmed/33805795 http://dx.doi.org/10.3390/nu13030933 |
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