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The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials

Many studies have shown that resveratrol has a lot of therapeutic effects on liver disorders. Its administration can significantly increase the survival rate after liver transplantation, reduce fat deposition and ischemia-induced necrosis and apoptosis in Wistar rats. Resveratrol can provide Liver p...

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Autores principales: Izzo, Carmine, Annunziata, Monica, Melara, Giuseppe, Sciorio, Roberta, Dallio, Marcello, Masarone, Mario, Federico, Alessandro, Persico, Marcello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999728/
https://www.ncbi.nlm.nih.gov/pubmed/33805795
http://dx.doi.org/10.3390/nu13030933
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author Izzo, Carmine
Annunziata, Monica
Melara, Giuseppe
Sciorio, Roberta
Dallio, Marcello
Masarone, Mario
Federico, Alessandro
Persico, Marcello
author_facet Izzo, Carmine
Annunziata, Monica
Melara, Giuseppe
Sciorio, Roberta
Dallio, Marcello
Masarone, Mario
Federico, Alessandro
Persico, Marcello
author_sort Izzo, Carmine
collection PubMed
description Many studies have shown that resveratrol has a lot of therapeutic effects on liver disorders. Its administration can significantly increase the survival rate after liver transplantation, reduce fat deposition and ischemia-induced necrosis and apoptosis in Wistar rats. Resveratrol can provide Liver protection against chemical, cholestatic, and alcohol-mediated damage. It can improve glucose metabolism and lipid profile, reduce liver fibrosis, and steatosis. Additionally, it is capable of altering the fatty acid composition of the liver cells. Resveratrol may be a potential treatment option for the management of non-alcoholic fatty liver disease (NAFLD) due to its anti-inflammatory, antioxidant, and calorie-restricting effects. There are also studies that have evaluated the effect of resveratrol on lipid and liver enzyme profiles among patients with metabolic syndrome (MetS) and related disorders. Based on the extent of liver disease worldwide and the need to find new treatment possibilities, this review critically examines current in vitro and in vivo preclinical studies and human clinical studies related to liver protection.
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spelling pubmed-79997282021-03-28 The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials Izzo, Carmine Annunziata, Monica Melara, Giuseppe Sciorio, Roberta Dallio, Marcello Masarone, Mario Federico, Alessandro Persico, Marcello Nutrients Review Many studies have shown that resveratrol has a lot of therapeutic effects on liver disorders. Its administration can significantly increase the survival rate after liver transplantation, reduce fat deposition and ischemia-induced necrosis and apoptosis in Wistar rats. Resveratrol can provide Liver protection against chemical, cholestatic, and alcohol-mediated damage. It can improve glucose metabolism and lipid profile, reduce liver fibrosis, and steatosis. Additionally, it is capable of altering the fatty acid composition of the liver cells. Resveratrol may be a potential treatment option for the management of non-alcoholic fatty liver disease (NAFLD) due to its anti-inflammatory, antioxidant, and calorie-restricting effects. There are also studies that have evaluated the effect of resveratrol on lipid and liver enzyme profiles among patients with metabolic syndrome (MetS) and related disorders. Based on the extent of liver disease worldwide and the need to find new treatment possibilities, this review critically examines current in vitro and in vivo preclinical studies and human clinical studies related to liver protection. MDPI 2021-03-13 /pmc/articles/PMC7999728/ /pubmed/33805795 http://dx.doi.org/10.3390/nu13030933 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Izzo, Carmine
Annunziata, Monica
Melara, Giuseppe
Sciorio, Roberta
Dallio, Marcello
Masarone, Mario
Federico, Alessandro
Persico, Marcello
The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials
title The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials
title_full The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials
title_fullStr The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials
title_full_unstemmed The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials
title_short The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials
title_sort role of resveratrol in liver disease: a comprehensive review from in vitro to clinical trials
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999728/
https://www.ncbi.nlm.nih.gov/pubmed/33805795
http://dx.doi.org/10.3390/nu13030933
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