Synthesis, Antiproliferative Activity and Radical Scavenging Ability of 5-O-Acyl Derivatives of Quercetin

Quercetin is a flavonoid that is found in many plant materials, including commonly eaten fruits and vegetables. The compound is well known for its wide range of biological activities. In this study, 5-O-acyl derivatives of quercetin were synthesised and assessed for their antiproliferative activity...

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Autores principales: Lo, Stephen, Leung, Euphemia, Fedrizzi, Bruno, Barker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999741/
https://www.ncbi.nlm.nih.gov/pubmed/33799363
http://dx.doi.org/10.3390/molecules26061608
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author Lo, Stephen
Leung, Euphemia
Fedrizzi, Bruno
Barker, David
author_facet Lo, Stephen
Leung, Euphemia
Fedrizzi, Bruno
Barker, David
author_sort Lo, Stephen
collection PubMed
description Quercetin is a flavonoid that is found in many plant materials, including commonly eaten fruits and vegetables. The compound is well known for its wide range of biological activities. In this study, 5-O-acyl derivatives of quercetin were synthesised and assessed for their antiproliferative activity against the HCT116 colon cancer and MDA-MB-231 breast cancer cell lines; and their radical scavenging activity against the 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical species. Four derivatives were found to have improved the antiproliferative activity compared to quercetin whilst retaining radical scavenging activity.
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spelling pubmed-79997412021-03-28 Synthesis, Antiproliferative Activity and Radical Scavenging Ability of 5-O-Acyl Derivatives of Quercetin Lo, Stephen Leung, Euphemia Fedrizzi, Bruno Barker, David Molecules Article Quercetin is a flavonoid that is found in many plant materials, including commonly eaten fruits and vegetables. The compound is well known for its wide range of biological activities. In this study, 5-O-acyl derivatives of quercetin were synthesised and assessed for their antiproliferative activity against the HCT116 colon cancer and MDA-MB-231 breast cancer cell lines; and their radical scavenging activity against the 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical species. Four derivatives were found to have improved the antiproliferative activity compared to quercetin whilst retaining radical scavenging activity. MDPI 2021-03-14 /pmc/articles/PMC7999741/ /pubmed/33799363 http://dx.doi.org/10.3390/molecules26061608 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lo, Stephen
Leung, Euphemia
Fedrizzi, Bruno
Barker, David
Synthesis, Antiproliferative Activity and Radical Scavenging Ability of 5-O-Acyl Derivatives of Quercetin
title Synthesis, Antiproliferative Activity and Radical Scavenging Ability of 5-O-Acyl Derivatives of Quercetin
title_full Synthesis, Antiproliferative Activity and Radical Scavenging Ability of 5-O-Acyl Derivatives of Quercetin
title_fullStr Synthesis, Antiproliferative Activity and Radical Scavenging Ability of 5-O-Acyl Derivatives of Quercetin
title_full_unstemmed Synthesis, Antiproliferative Activity and Radical Scavenging Ability of 5-O-Acyl Derivatives of Quercetin
title_short Synthesis, Antiproliferative Activity and Radical Scavenging Ability of 5-O-Acyl Derivatives of Quercetin
title_sort synthesis, antiproliferative activity and radical scavenging ability of 5-o-acyl derivatives of quercetin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999741/
https://www.ncbi.nlm.nih.gov/pubmed/33799363
http://dx.doi.org/10.3390/molecules26061608
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