TYK2 Promoter Variant Is Associated with Impaired Insulin Secretion and Lower Insulin Resistance in Japanese Type 2 Diabetes Patients

Accumulating evidence has suggested that viral infection causes type 1 diabetes due to direct β-cell damage and the triggering of autoimmune reactivity to β cells. Here, we elucidated that the tyrosine kinase 2 (Tyk2) gene, encoding an interferon receptor signaling molecule, is responsible for virus...

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Detalles Bibliográficos
Autores principales: Mori, Hitoe, Takahashi, Hirokazu, Mine, Keiichiro, Higashimoto, Ken, Inoue, Kanako, Kojima, Motoyasu, Kuroki, Shigetaka, Eguchi, Takahisa, Ono, Yasuhiro, Inuzuka, Sadataka, Soejima, Hidenobu, Nagafuchi, Seiho, Anzai, Keizo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999758/
https://www.ncbi.nlm.nih.gov/pubmed/33799705
http://dx.doi.org/10.3390/genes12030400

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