The Importance of Epigenetics in Diagnostics and Treatment of Major Depressive Disorder

Recent studies imply that there is a tight association between epigenetics and a molecular mechanism of major depressive disorder (MDD). Epigenetic modifications, i.e., DNA methylation, post-translational histone modification and interference of microRNA (miRNA) or long non-coding RNA (lncRNA), are...

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Autores principales: Czarny, Piotr, Białek, Katarzyna, Ziółkowska, Sylwia, Strycharz, Justyna, Barszczewska, Gabriela, Sliwinski, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999864/
https://www.ncbi.nlm.nih.gov/pubmed/33804455
http://dx.doi.org/10.3390/jpm11030167
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author Czarny, Piotr
Białek, Katarzyna
Ziółkowska, Sylwia
Strycharz, Justyna
Barszczewska, Gabriela
Sliwinski, Tomasz
author_facet Czarny, Piotr
Białek, Katarzyna
Ziółkowska, Sylwia
Strycharz, Justyna
Barszczewska, Gabriela
Sliwinski, Tomasz
author_sort Czarny, Piotr
collection PubMed
description Recent studies imply that there is a tight association between epigenetics and a molecular mechanism of major depressive disorder (MDD). Epigenetic modifications, i.e., DNA methylation, post-translational histone modification and interference of microRNA (miRNA) or long non-coding RNA (lncRNA), are able to influence the severity of the disease and the outcome of the therapy. This article summarizes the most recent literature data on this topic, i.e., usage of histone deacetylases as therapeutic agents with an antidepressant effect and miRNAs or lncRNAs as markers of depression. Due to the noteworthy potential of the role of epigenetics in MDD diagnostics and therapy, we have gathered the most relevant data in this area.
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spelling pubmed-79998642021-03-28 The Importance of Epigenetics in Diagnostics and Treatment of Major Depressive Disorder Czarny, Piotr Białek, Katarzyna Ziółkowska, Sylwia Strycharz, Justyna Barszczewska, Gabriela Sliwinski, Tomasz J Pers Med Review Recent studies imply that there is a tight association between epigenetics and a molecular mechanism of major depressive disorder (MDD). Epigenetic modifications, i.e., DNA methylation, post-translational histone modification and interference of microRNA (miRNA) or long non-coding RNA (lncRNA), are able to influence the severity of the disease and the outcome of the therapy. This article summarizes the most recent literature data on this topic, i.e., usage of histone deacetylases as therapeutic agents with an antidepressant effect and miRNAs or lncRNAs as markers of depression. Due to the noteworthy potential of the role of epigenetics in MDD diagnostics and therapy, we have gathered the most relevant data in this area. MDPI 2021-03-01 /pmc/articles/PMC7999864/ /pubmed/33804455 http://dx.doi.org/10.3390/jpm11030167 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Czarny, Piotr
Białek, Katarzyna
Ziółkowska, Sylwia
Strycharz, Justyna
Barszczewska, Gabriela
Sliwinski, Tomasz
The Importance of Epigenetics in Diagnostics and Treatment of Major Depressive Disorder
title The Importance of Epigenetics in Diagnostics and Treatment of Major Depressive Disorder
title_full The Importance of Epigenetics in Diagnostics and Treatment of Major Depressive Disorder
title_fullStr The Importance of Epigenetics in Diagnostics and Treatment of Major Depressive Disorder
title_full_unstemmed The Importance of Epigenetics in Diagnostics and Treatment of Major Depressive Disorder
title_short The Importance of Epigenetics in Diagnostics and Treatment of Major Depressive Disorder
title_sort importance of epigenetics in diagnostics and treatment of major depressive disorder
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999864/
https://www.ncbi.nlm.nih.gov/pubmed/33804455
http://dx.doi.org/10.3390/jpm11030167
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