In Silico Drug Repurposing by Structural Alteration after Induced Fit: Discovery of a Candidate Agent for Recovery of Nucleotide Excision Repair in Xeroderma Pigmentosum Group D Mutant (R683W)

Xeroderma pigmentosum complementation group D (XPD) is a UV-sensitive syndrome and a rare incurable genetic disease which is caused by the genetic mutation of the excision repair cross-complementation group 2 gene (ERCC2). Patients who harbor only XPD R683W mutant protein develop severe photosensiti...

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Detalles Bibliográficos
Autores principales: Takaoka, Yutaka, Ohta, Mika, Tateishi, Satoshi, Sugano, Aki, Nakano, Eiji, Miura, Kenji, Suzuki, Takashi, Nishigori, Chikako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999925/
https://www.ncbi.nlm.nih.gov/pubmed/33802476
http://dx.doi.org/10.3390/biomedicines9030249

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