Activity of Mannose-Binding Lectin on Bacterial-Infected Chickens—A Review

SIMPLE SUMMARY: In the quest to combat bacterial-related diseases in chickens, different methods, of which some are less economical and less effective on the long-term, have been adapted. However, chickens possess mannose-binding lectin (MBL) which could be vital in managing pathogenic bacteria in chickens. MBL is one of the soluble proteins secreted by the chicken’s innate immune system which can be activated when chickens are exposed to chicken-related diseases. This review explains how mannose-binding lectin activation can help in fighting bacterial pathogens in chickens. This knowledge is believed to reduce incessant use of antibiotics and to assist in developing a profitable breeding program with less or no adverse effect on the chicken, human and the environment. ABSTRACT: In recent years, diseases caused by pathogenic bacteria have profoundly impacted chicken production by causing economic loss in chicken products and by-product revenues. MBL (mannose-binding lectin) is part of the innate immune system (IIS), which is the host’s first line defense against pathogens. The IIS functions centrally by identifying pathogen-specific microorganism-associated molecular patterns (MAMPs) with the help of pattern recognition receptors (PRRs). Studies have classified mannose-binding lectin (MBL) as one of the PRR molecules which belong to the C-type lectin family. The protective role of MBL lies in its ability to activate the complement system via the lectin pathway and there seems to be a direct link between the chicken’s health status and the MBL concentration in the serum. Several methods have been used to detect the presence, the level and the structure of MBL in chickens such as Enzyme-linked immunosorbent assay (ELISA), Polymerase Chain Reaction (PCR) among others. The concentration of MBL in the chicken ranges from 0.4 to 35 µg/mL and can be at peak levels at three to nine days at entry of pathogens. The variations observed are known to depend on the bacterial strains, breed and age of the chicken and possibly the feed manipulation strategies. However, when chicken MBL (cMBL) becomes deficient, it can result in malfunctioning of the innate immune system, which can predispose chickens to diseases. This article aimed to discuss the importance and components of mannose-binding lectin (MBL) in chickens, its mode of actions, and the different methods used to detect MBL. Therefore, more studies are recommended to explore the causes for low and high cMBL production in chicken breeds and the possible effect of feed manipulation strategies in enhancing cMBL production.