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Two Faces of Autophagy in the Struggle against Cancer
Autophagy can play a double role in cancerogenesis: it can either inhibit further development of the disease or protect cells, causing stimulation of tumour growth. This phenomenon is called “autophagy paradox”, and is characterised by the features that the autophagy process provides the necessary s...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000091/ https://www.ncbi.nlm.nih.gov/pubmed/33804163 http://dx.doi.org/10.3390/ijms22062981 |
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author | Chmurska, Anna Matczak, Karolina Marczak, Agnieszka |
author_facet | Chmurska, Anna Matczak, Karolina Marczak, Agnieszka |
author_sort | Chmurska, Anna |
collection | PubMed |
description | Autophagy can play a double role in cancerogenesis: it can either inhibit further development of the disease or protect cells, causing stimulation of tumour growth. This phenomenon is called “autophagy paradox”, and is characterised by the features that the autophagy process provides the necessary substrates for biosynthesis to meet the cell’s energy needs, and that the over-programmed activity of this process can lead to cell death through apoptosis. The fight against cancer is a difficult process due to high levels of resistance to chemotherapy and radiotherapy. More and more research is indicating that autophagy may play a very important role in the development of resistance by protecting cancer cells, which is why autophagy in cancer therapy can act as a “double-edged sword”. This paper attempts to analyse the influence of autophagy and cancer stem cells on tumour development, and to compare new therapeutic strategies based on the modulation of these processes. |
format | Online Article Text |
id | pubmed-8000091 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80000912021-03-28 Two Faces of Autophagy in the Struggle against Cancer Chmurska, Anna Matczak, Karolina Marczak, Agnieszka Int J Mol Sci Review Autophagy can play a double role in cancerogenesis: it can either inhibit further development of the disease or protect cells, causing stimulation of tumour growth. This phenomenon is called “autophagy paradox”, and is characterised by the features that the autophagy process provides the necessary substrates for biosynthesis to meet the cell’s energy needs, and that the over-programmed activity of this process can lead to cell death through apoptosis. The fight against cancer is a difficult process due to high levels of resistance to chemotherapy and radiotherapy. More and more research is indicating that autophagy may play a very important role in the development of resistance by protecting cancer cells, which is why autophagy in cancer therapy can act as a “double-edged sword”. This paper attempts to analyse the influence of autophagy and cancer stem cells on tumour development, and to compare new therapeutic strategies based on the modulation of these processes. MDPI 2021-03-15 /pmc/articles/PMC8000091/ /pubmed/33804163 http://dx.doi.org/10.3390/ijms22062981 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chmurska, Anna Matczak, Karolina Marczak, Agnieszka Two Faces of Autophagy in the Struggle against Cancer |
title | Two Faces of Autophagy in the Struggle against Cancer |
title_full | Two Faces of Autophagy in the Struggle against Cancer |
title_fullStr | Two Faces of Autophagy in the Struggle against Cancer |
title_full_unstemmed | Two Faces of Autophagy in the Struggle against Cancer |
title_short | Two Faces of Autophagy in the Struggle against Cancer |
title_sort | two faces of autophagy in the struggle against cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000091/ https://www.ncbi.nlm.nih.gov/pubmed/33804163 http://dx.doi.org/10.3390/ijms22062981 |
work_keys_str_mv | AT chmurskaanna twofacesofautophagyinthestruggleagainstcancer AT matczakkarolina twofacesofautophagyinthestruggleagainstcancer AT marczakagnieszka twofacesofautophagyinthestruggleagainstcancer |