Cargando…
Menstrual Headache in Women with Chronic Migraine Treated with Erenumab: An Observational Case Series
Background: We aimed to assess the differences between menstrual and non-menstrual headache in women with chronic migraine treated with erenumab. Methods: We included fertile women from a single center. Patients were defined as responders to erenumab if reporting a ≥50% decrease in monthly headache...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000210/ https://www.ncbi.nlm.nih.gov/pubmed/33805838 http://dx.doi.org/10.3390/brainsci11030370 |
_version_ | 1783670951218511872 |
---|---|
author | Ornello, Raffaele Frattale, Ilaria Caponnetto, Valeria De Matteis, Eleonora Pistoia, Francesca Sacco, Simona |
author_facet | Ornello, Raffaele Frattale, Ilaria Caponnetto, Valeria De Matteis, Eleonora Pistoia, Francesca Sacco, Simona |
author_sort | Ornello, Raffaele |
collection | PubMed |
description | Background: We aimed to assess the differences between menstrual and non-menstrual headache in women with chronic migraine treated with erenumab. Methods: We included fertile women from a single center. Patients were defined as responders to erenumab if reporting a ≥50% decrease in monthly headache days, as compared to pre-treatment for more than half of the treatment period. Premenstrual days were defined as the two days preceding menstruation, while menstrual days were defined as the first three days of menstruation. Results: We included 18 women (11 erenumab responders and 7 erenumab non-responders) contributing to a total of 103 menstrual cycles and 2926 days. The proportion of headache days was higher in menstrual than in premenstrual and non-menstrual days in erenumab responders (34.4% vs. 14.8% vs. 16.3%, respectively; p < 0.001) and in erenumab non-responders (71.4% vs. 53.6% vs. 48.3%, respectively; p < 0.001). Headache days with ≥2 acute medications were higher in menstrual than in premenstrual or non-menstrual headache days in erenumab non-responders (p = 0.002) but not in erenumab responders (p = 0.620). Conclusions: Our data suggest that migraine is more frequent during than outside menstrual days even in women treated with erenumab. |
format | Online Article Text |
id | pubmed-8000210 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80002102021-03-28 Menstrual Headache in Women with Chronic Migraine Treated with Erenumab: An Observational Case Series Ornello, Raffaele Frattale, Ilaria Caponnetto, Valeria De Matteis, Eleonora Pistoia, Francesca Sacco, Simona Brain Sci Article Background: We aimed to assess the differences between menstrual and non-menstrual headache in women with chronic migraine treated with erenumab. Methods: We included fertile women from a single center. Patients were defined as responders to erenumab if reporting a ≥50% decrease in monthly headache days, as compared to pre-treatment for more than half of the treatment period. Premenstrual days were defined as the two days preceding menstruation, while menstrual days were defined as the first three days of menstruation. Results: We included 18 women (11 erenumab responders and 7 erenumab non-responders) contributing to a total of 103 menstrual cycles and 2926 days. The proportion of headache days was higher in menstrual than in premenstrual and non-menstrual days in erenumab responders (34.4% vs. 14.8% vs. 16.3%, respectively; p < 0.001) and in erenumab non-responders (71.4% vs. 53.6% vs. 48.3%, respectively; p < 0.001). Headache days with ≥2 acute medications were higher in menstrual than in premenstrual or non-menstrual headache days in erenumab non-responders (p = 0.002) but not in erenumab responders (p = 0.620). Conclusions: Our data suggest that migraine is more frequent during than outside menstrual days even in women treated with erenumab. MDPI 2021-03-13 /pmc/articles/PMC8000210/ /pubmed/33805838 http://dx.doi.org/10.3390/brainsci11030370 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Ornello, Raffaele Frattale, Ilaria Caponnetto, Valeria De Matteis, Eleonora Pistoia, Francesca Sacco, Simona Menstrual Headache in Women with Chronic Migraine Treated with Erenumab: An Observational Case Series |
title | Menstrual Headache in Women with Chronic Migraine Treated with Erenumab: An Observational Case Series |
title_full | Menstrual Headache in Women with Chronic Migraine Treated with Erenumab: An Observational Case Series |
title_fullStr | Menstrual Headache in Women with Chronic Migraine Treated with Erenumab: An Observational Case Series |
title_full_unstemmed | Menstrual Headache in Women with Chronic Migraine Treated with Erenumab: An Observational Case Series |
title_short | Menstrual Headache in Women with Chronic Migraine Treated with Erenumab: An Observational Case Series |
title_sort | menstrual headache in women with chronic migraine treated with erenumab: an observational case series |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000210/ https://www.ncbi.nlm.nih.gov/pubmed/33805838 http://dx.doi.org/10.3390/brainsci11030370 |
work_keys_str_mv | AT ornelloraffaele menstrualheadacheinwomenwithchronicmigrainetreatedwitherenumabanobservationalcaseseries AT frattaleilaria menstrualheadacheinwomenwithchronicmigrainetreatedwitherenumabanobservationalcaseseries AT caponnettovaleria menstrualheadacheinwomenwithchronicmigrainetreatedwitherenumabanobservationalcaseseries AT dematteiseleonora menstrualheadacheinwomenwithchronicmigrainetreatedwitherenumabanobservationalcaseseries AT pistoiafrancesca menstrualheadacheinwomenwithchronicmigrainetreatedwitherenumabanobservationalcaseseries AT saccosimona menstrualheadacheinwomenwithchronicmigrainetreatedwitherenumabanobservationalcaseseries |