Design, Synthesis and Characterization of HIV-1 CA-Targeting Small Molecules: Conformational Restriction of PF74

Small molecules targeting the PF74 binding site of the HIV-1 capsid protein (CA) confer potent and mechanistically unique antiviral activities. Structural modifications of PF74 could further the understanding of ligand binding modes, diversify ligand chemical classes, and allow identification of new...

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Detalles Bibliográficos
Autores principales: Sahani, Rajkumar Lalji, Diana-Rivero, Raquel, Vernekar, Sanjeev Kumar V., Wang, Lei, Du, Haijuan, Zhang, Huanchun, Castaner, Andres Emanuelli, Casey, Mary C., Kirby, Karen A., Tedbury, Philip R., Xie, Jiashu, Sarafianos, Stefan G., Wang, Zhengqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000227/
https://www.ncbi.nlm.nih.gov/pubmed/33804121
http://dx.doi.org/10.3390/v13030479

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