Immature Plasma Cell Myeloma Mimics Metastatic Renal Cell Carcinoma on (18)F-PSMA-1007 PET/CT Due to Endothelial PSMA-Expression

We present a 71-year-old female patient who underwent (18)F-PSMA-1007 PET/CT for suspected metastatic renal cell carcinoma (RCC), as RCC also shows high PSMA-expression in tumor neovascularization. (18)F-PSMA-1007 PET/CT showed a high PSMA-avidity in the renal tumor, enlarged intra-abdominal and med...

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Detalles Bibliográficos
Autores principales: Mittlmeier, Lena M., Ledderose, Stephan T., Schott, Melanie, Brendel, Matthias, Beyer, Leonie, Theurich, Sebastian, Mayr, Doris, Walz, Christoph, Kunz, Wolfgang G., Ricke, Jens, Bartenstein, Peter, Ilhan, Harun, Staehler, Michael, Unterrainer, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000301/
https://www.ncbi.nlm.nih.gov/pubmed/33802288
http://dx.doi.org/10.3390/diagnostics11030423
Descripción
Sumario:We present a 71-year-old female patient who underwent (18)F-PSMA-1007 PET/CT for suspected metastatic renal cell carcinoma (RCC), as RCC also shows high PSMA-expression in tumor neovascularization. (18)F-PSMA-1007 PET/CT showed a high PSMA-avidity in the renal tumor, enlarged intra-abdominal and mediastinal lymph nodes. Moreover, PSMA-positive pleural, pulmonal and osseous lesions were found. However, histopathology revealed an immature plasma cell myeloma with an endothelial PSMA-expression of the neovasculature. This case illustrates the increased PSMA-avidity in multiple myeloma and highlights PSMA as a potential theragnostic target in multiple myeloma. For clinical routine, lymphatic diseases such as extramedullary myeloma should be considered as differential diagnosis in PSMA-avid renal masses on PET/CT.

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