Immature Plasma Cell Myeloma Mimics Metastatic Renal Cell Carcinoma on (18)F-PSMA-1007 PET/CT Due to Endothelial PSMA-Expression

We present a 71-year-old female patient who underwent (18)F-PSMA-1007 PET/CT for suspected metastatic renal cell carcinoma (RCC), as RCC also shows high PSMA-expression in tumor neovascularization. (18)F-PSMA-1007 PET/CT showed a high PSMA-avidity in the renal tumor, enlarged intra-abdominal and med...

Descripción completa

Detalles Bibliográficos
Autores principales: Mittlmeier, Lena M., Ledderose, Stephan T., Schott, Melanie, Brendel, Matthias, Beyer, Leonie, Theurich, Sebastian, Mayr, Doris, Walz, Christoph, Kunz, Wolfgang G., Ricke, Jens, Bartenstein, Peter, Ilhan, Harun, Staehler, Michael, Unterrainer, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Interesting Images
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000301/
https://www.ncbi.nlm.nih.gov/pubmed/33802288
http://dx.doi.org/10.3390/diagnostics11030423
_version_ 1783670971423522816
author Mittlmeier, Lena M.
Ledderose, Stephan T.
Schott, Melanie
Brendel, Matthias
Beyer, Leonie
Theurich, Sebastian
Mayr, Doris
Walz, Christoph
Kunz, Wolfgang G.
Ricke, Jens
Bartenstein, Peter
Ilhan, Harun
Staehler, Michael
Unterrainer, Marcus
author_facet Mittlmeier, Lena M.
Ledderose, Stephan T.
Schott, Melanie
Brendel, Matthias
Beyer, Leonie
Theurich, Sebastian
Mayr, Doris
Walz, Christoph
Kunz, Wolfgang G.
Ricke, Jens
Bartenstein, Peter
Ilhan, Harun
Staehler, Michael
Unterrainer, Marcus
author_sort Mittlmeier, Lena M.
collection PubMed
description We present a 71-year-old female patient who underwent (18)F-PSMA-1007 PET/CT for suspected metastatic renal cell carcinoma (RCC), as RCC also shows high PSMA-expression in tumor neovascularization. (18)F-PSMA-1007 PET/CT showed a high PSMA-avidity in the renal tumor, enlarged intra-abdominal and mediastinal lymph nodes. Moreover, PSMA-positive pleural, pulmonal and osseous lesions were found. However, histopathology revealed an immature plasma cell myeloma with an endothelial PSMA-expression of the neovasculature. This case illustrates the increased PSMA-avidity in multiple myeloma and highlights PSMA as a potential theragnostic target in multiple myeloma. For clinical routine, lymphatic diseases such as extramedullary myeloma should be considered as differential diagnosis in PSMA-avid renal masses on PET/CT.
format Online
Article
Text
id pubmed-8000301
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-80003012021-03-28 Immature Plasma Cell Myeloma Mimics Metastatic Renal Cell Carcinoma on (18)F-PSMA-1007 PET/CT Due to Endothelial PSMA-Expression Mittlmeier, Lena M. Ledderose, Stephan T. Schott, Melanie Brendel, Matthias Beyer, Leonie Theurich, Sebastian Mayr, Doris Walz, Christoph Kunz, Wolfgang G. Ricke, Jens Bartenstein, Peter Ilhan, Harun Staehler, Michael Unterrainer, Marcus Diagnostics (Basel) Interesting Images We present a 71-year-old female patient who underwent (18)F-PSMA-1007 PET/CT for suspected metastatic renal cell carcinoma (RCC), as RCC also shows high PSMA-expression in tumor neovascularization. (18)F-PSMA-1007 PET/CT showed a high PSMA-avidity in the renal tumor, enlarged intra-abdominal and mediastinal lymph nodes. Moreover, PSMA-positive pleural, pulmonal and osseous lesions were found. However, histopathology revealed an immature plasma cell myeloma with an endothelial PSMA-expression of the neovasculature. This case illustrates the increased PSMA-avidity in multiple myeloma and highlights PSMA as a potential theragnostic target in multiple myeloma. For clinical routine, lymphatic diseases such as extramedullary myeloma should be considered as differential diagnosis in PSMA-avid renal masses on PET/CT. MDPI 2021-03-03 /pmc/articles/PMC8000301/ /pubmed/33802288 http://dx.doi.org/10.3390/diagnostics11030423 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Interesting Images
Mittlmeier, Lena M.
Ledderose, Stephan T.
Schott, Melanie
Brendel, Matthias
Beyer, Leonie
Theurich, Sebastian
Mayr, Doris
Walz, Christoph
Kunz, Wolfgang G.
Ricke, Jens
Bartenstein, Peter
Ilhan, Harun
Staehler, Michael
Unterrainer, Marcus
Immature Plasma Cell Myeloma Mimics Metastatic Renal Cell Carcinoma on (18)F-PSMA-1007 PET/CT Due to Endothelial PSMA-Expression
title Immature Plasma Cell Myeloma Mimics Metastatic Renal Cell Carcinoma on (18)F-PSMA-1007 PET/CT Due to Endothelial PSMA-Expression
title_full Immature Plasma Cell Myeloma Mimics Metastatic Renal Cell Carcinoma on (18)F-PSMA-1007 PET/CT Due to Endothelial PSMA-Expression
title_fullStr Immature Plasma Cell Myeloma Mimics Metastatic Renal Cell Carcinoma on (18)F-PSMA-1007 PET/CT Due to Endothelial PSMA-Expression
title_full_unstemmed Immature Plasma Cell Myeloma Mimics Metastatic Renal Cell Carcinoma on (18)F-PSMA-1007 PET/CT Due to Endothelial PSMA-Expression
title_short Immature Plasma Cell Myeloma Mimics Metastatic Renal Cell Carcinoma on (18)F-PSMA-1007 PET/CT Due to Endothelial PSMA-Expression
title_sort immature plasma cell myeloma mimics metastatic renal cell carcinoma on (18)f-psma-1007 pet/ct due to endothelial psma-expression
topic Interesting Images
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000301/
https://www.ncbi.nlm.nih.gov/pubmed/33802288
http://dx.doi.org/10.3390/diagnostics11030423
work_keys_str_mv AT mittlmeierlenam immatureplasmacellmyelomamimicsmetastaticrenalcellcarcinomaon18fpsma1007petctduetoendothelialpsmaexpression
AT ledderosestephant immatureplasmacellmyelomamimicsmetastaticrenalcellcarcinomaon18fpsma1007petctduetoendothelialpsmaexpression
AT schottmelanie immatureplasmacellmyelomamimicsmetastaticrenalcellcarcinomaon18fpsma1007petctduetoendothelialpsmaexpression
AT brendelmatthias immatureplasmacellmyelomamimicsmetastaticrenalcellcarcinomaon18fpsma1007petctduetoendothelialpsmaexpression
AT beyerleonie immatureplasmacellmyelomamimicsmetastaticrenalcellcarcinomaon18fpsma1007petctduetoendothelialpsmaexpression
AT theurichsebastian immatureplasmacellmyelomamimicsmetastaticrenalcellcarcinomaon18fpsma1007petctduetoendothelialpsmaexpression
AT mayrdoris immatureplasmacellmyelomamimicsmetastaticrenalcellcarcinomaon18fpsma1007petctduetoendothelialpsmaexpression
AT walzchristoph immatureplasmacellmyelomamimicsmetastaticrenalcellcarcinomaon18fpsma1007petctduetoendothelialpsmaexpression
AT kunzwolfgangg immatureplasmacellmyelomamimicsmetastaticrenalcellcarcinomaon18fpsma1007petctduetoendothelialpsmaexpression
AT rickejens immatureplasmacellmyelomamimicsmetastaticrenalcellcarcinomaon18fpsma1007petctduetoendothelialpsmaexpression
AT bartensteinpeter immatureplasmacellmyelomamimicsmetastaticrenalcellcarcinomaon18fpsma1007petctduetoendothelialpsmaexpression
AT ilhanharun immatureplasmacellmyelomamimicsmetastaticrenalcellcarcinomaon18fpsma1007petctduetoendothelialpsmaexpression
AT staehlermichael immatureplasmacellmyelomamimicsmetastaticrenalcellcarcinomaon18fpsma1007petctduetoendothelialpsmaexpression
AT unterrainermarcus immatureplasmacellmyelomamimicsmetastaticrenalcellcarcinomaon18fpsma1007petctduetoendothelialpsmaexpression

Ejemplares similares