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Maternal Psychological and Biological Factors Associated to Gestational Complications

Early detection of gestational complications is a priority in obstetrics. In our social context, this is linked to maternity age. Most studies are focused on biological factors. However, pregnancy is also influenced by social and psychological factors, which have not been deeply explored. We aimed t...

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Autores principales: Ramiro-Cortijo, David, de la Calle, Maria, Benitez, Vanesa, Gila-Diaz, Andrea, Moreno-Jiménez, Bernardo, Arribas, Silvia M., Garrosa, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000308/
https://www.ncbi.nlm.nih.gov/pubmed/33807903
http://dx.doi.org/10.3390/jpm11030183
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author Ramiro-Cortijo, David
de la Calle, Maria
Benitez, Vanesa
Gila-Diaz, Andrea
Moreno-Jiménez, Bernardo
Arribas, Silvia M.
Garrosa, Eva
author_facet Ramiro-Cortijo, David
de la Calle, Maria
Benitez, Vanesa
Gila-Diaz, Andrea
Moreno-Jiménez, Bernardo
Arribas, Silvia M.
Garrosa, Eva
author_sort Ramiro-Cortijo, David
collection PubMed
description Early detection of gestational complications is a priority in obstetrics. In our social context, this is linked to maternity age. Most studies are focused on biological factors. However, pregnancy is also influenced by social and psychological factors, which have not been deeply explored. We aimed to identify biopsychosocial risk and protective factors associated with the development of maternal and fetal complications. We enrolled 182 healthy pregnant women, and plasma melatonin and cortisol levels were measured in the first trimester by chemiluminescent immunoassays. At different time points along gestation, women answered several questionnaires (positive and negative affect schedule, hospital anxiety and depression scale, pregnancy concerns scale, life orientation test, resilience scale, life satisfaction scale and life–work conflicts scale). They were followed up until delivery and categorized as normal pregnancy, maternal or fetal complications. Maternal complications were associated with low melatonin (OR = 0.99 [0.98; 1.00]; p-value = 0.08) and life satisfaction (OR = 0.64 [0.41; 0.93]; p-value = 0.03) and fetal complications were associated with high cortisol (OR = 1.06 [1.02; 1.13]; p-value = 0.04), anxiety (OR = 2.21 [1.10; 4.55]; p-value = 0.03) and life–work conflicts (OR = 1.92 [1.04; 3.75]; p-value = 0.05). We conclude that psychological factors influence pregnancy outcomes in association with melatonin and cortisol alterations. High maternal melatonin and life satisfaction levels could be potential protective factors against the development of maternal complications during pregnancy. Low anxiety and cortisol levels and reduced work–life conflicts could prevent fetal complications.
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spelling pubmed-80003082021-03-28 Maternal Psychological and Biological Factors Associated to Gestational Complications Ramiro-Cortijo, David de la Calle, Maria Benitez, Vanesa Gila-Diaz, Andrea Moreno-Jiménez, Bernardo Arribas, Silvia M. Garrosa, Eva J Pers Med Article Early detection of gestational complications is a priority in obstetrics. In our social context, this is linked to maternity age. Most studies are focused on biological factors. However, pregnancy is also influenced by social and psychological factors, which have not been deeply explored. We aimed to identify biopsychosocial risk and protective factors associated with the development of maternal and fetal complications. We enrolled 182 healthy pregnant women, and plasma melatonin and cortisol levels were measured in the first trimester by chemiluminescent immunoassays. At different time points along gestation, women answered several questionnaires (positive and negative affect schedule, hospital anxiety and depression scale, pregnancy concerns scale, life orientation test, resilience scale, life satisfaction scale and life–work conflicts scale). They were followed up until delivery and categorized as normal pregnancy, maternal or fetal complications. Maternal complications were associated with low melatonin (OR = 0.99 [0.98; 1.00]; p-value = 0.08) and life satisfaction (OR = 0.64 [0.41; 0.93]; p-value = 0.03) and fetal complications were associated with high cortisol (OR = 1.06 [1.02; 1.13]; p-value = 0.04), anxiety (OR = 2.21 [1.10; 4.55]; p-value = 0.03) and life–work conflicts (OR = 1.92 [1.04; 3.75]; p-value = 0.05). We conclude that psychological factors influence pregnancy outcomes in association with melatonin and cortisol alterations. High maternal melatonin and life satisfaction levels could be potential protective factors against the development of maternal complications during pregnancy. Low anxiety and cortisol levels and reduced work–life conflicts could prevent fetal complications. MDPI 2021-03-05 /pmc/articles/PMC8000308/ /pubmed/33807903 http://dx.doi.org/10.3390/jpm11030183 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Ramiro-Cortijo, David
de la Calle, Maria
Benitez, Vanesa
Gila-Diaz, Andrea
Moreno-Jiménez, Bernardo
Arribas, Silvia M.
Garrosa, Eva
Maternal Psychological and Biological Factors Associated to Gestational Complications
title Maternal Psychological and Biological Factors Associated to Gestational Complications
title_full Maternal Psychological and Biological Factors Associated to Gestational Complications
title_fullStr Maternal Psychological and Biological Factors Associated to Gestational Complications
title_full_unstemmed Maternal Psychological and Biological Factors Associated to Gestational Complications
title_short Maternal Psychological and Biological Factors Associated to Gestational Complications
title_sort maternal psychological and biological factors associated to gestational complications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000308/
https://www.ncbi.nlm.nih.gov/pubmed/33807903
http://dx.doi.org/10.3390/jpm11030183
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