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Spectral Decomposition and Sound Source Localization of Highly Disturbed Flow through a Severe Arterial Stenosis
For the early detection of atherosclerosis, it is imperative to explore the capabilities of new, effective noninvasive diagnosis techniques to significantly reduce the associated treatment costs and mortality rates. In this study, a multifaceted comprehensive approach involving advanced computationa...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000318/ https://www.ncbi.nlm.nih.gov/pubmed/33806695 http://dx.doi.org/10.3390/bioengineering8030034 |
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author | Khalili, Fardin Gamage, Peshala T. Taebi, Amirtahà Johnson, Mark E. Roberts, Randal B. Mitchel, John |
author_facet | Khalili, Fardin Gamage, Peshala T. Taebi, Amirtahà Johnson, Mark E. Roberts, Randal B. Mitchel, John |
author_sort | Khalili, Fardin |
collection | PubMed |
description | For the early detection of atherosclerosis, it is imperative to explore the capabilities of new, effective noninvasive diagnosis techniques to significantly reduce the associated treatment costs and mortality rates. In this study, a multifaceted comprehensive approach involving advanced computational fluid dynamics combined with signal processing techniques was exploited to investigate the highly turbulent fluctuating flow through arterial stenosis. The focus was on localizing high-energy mechano-acoustic source potential to transmit to the epidermal surface. The flow analysis results showed the existence of turbulent pressure fluctuations inside the stenosis and in the post-stenotic region. After analyzing the turbulent kinetic energy and pressure fluctuations on the flow centerline and the vessel wall, the point of maximum excitation in the flow was observed around two diameters downstream of the stenosis within the fluctuating zone. It was also found that the concentration of pressure fluctuation closer to the wall was higher inside the stenosis compared to the post-stenotic region. Additionally, the visualization of the most energetic proper orthogonal decomposition (POD) mode and spectral decomposition of the flow indicated that the break frequencies ranged from 80 to 220 Hz and were correlated to the eddies generated within these regions. |
format | Online Article Text |
id | pubmed-8000318 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80003182021-03-28 Spectral Decomposition and Sound Source Localization of Highly Disturbed Flow through a Severe Arterial Stenosis Khalili, Fardin Gamage, Peshala T. Taebi, Amirtahà Johnson, Mark E. Roberts, Randal B. Mitchel, John Bioengineering (Basel) Article For the early detection of atherosclerosis, it is imperative to explore the capabilities of new, effective noninvasive diagnosis techniques to significantly reduce the associated treatment costs and mortality rates. In this study, a multifaceted comprehensive approach involving advanced computational fluid dynamics combined with signal processing techniques was exploited to investigate the highly turbulent fluctuating flow through arterial stenosis. The focus was on localizing high-energy mechano-acoustic source potential to transmit to the epidermal surface. The flow analysis results showed the existence of turbulent pressure fluctuations inside the stenosis and in the post-stenotic region. After analyzing the turbulent kinetic energy and pressure fluctuations on the flow centerline and the vessel wall, the point of maximum excitation in the flow was observed around two diameters downstream of the stenosis within the fluctuating zone. It was also found that the concentration of pressure fluctuation closer to the wall was higher inside the stenosis compared to the post-stenotic region. Additionally, the visualization of the most energetic proper orthogonal decomposition (POD) mode and spectral decomposition of the flow indicated that the break frequencies ranged from 80 to 220 Hz and were correlated to the eddies generated within these regions. MDPI 2021-03-04 /pmc/articles/PMC8000318/ /pubmed/33806695 http://dx.doi.org/10.3390/bioengineering8030034 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Khalili, Fardin Gamage, Peshala T. Taebi, Amirtahà Johnson, Mark E. Roberts, Randal B. Mitchel, John Spectral Decomposition and Sound Source Localization of Highly Disturbed Flow through a Severe Arterial Stenosis |
title | Spectral Decomposition and Sound Source Localization of Highly Disturbed Flow through a Severe Arterial Stenosis |
title_full | Spectral Decomposition and Sound Source Localization of Highly Disturbed Flow through a Severe Arterial Stenosis |
title_fullStr | Spectral Decomposition and Sound Source Localization of Highly Disturbed Flow through a Severe Arterial Stenosis |
title_full_unstemmed | Spectral Decomposition and Sound Source Localization of Highly Disturbed Flow through a Severe Arterial Stenosis |
title_short | Spectral Decomposition and Sound Source Localization of Highly Disturbed Flow through a Severe Arterial Stenosis |
title_sort | spectral decomposition and sound source localization of highly disturbed flow through a severe arterial stenosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000318/ https://www.ncbi.nlm.nih.gov/pubmed/33806695 http://dx.doi.org/10.3390/bioengineering8030034 |
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