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An Insight into the Anxiolytic and Antidepressant-Like Proprieties of Carum carvi L. and Their Association with Its Antioxidant Activity

Depression and anxiety are widespread illnesses whose consequences on patients’ social and professional lives are becoming ever more dangerous and severe. The study’s objective is to explore the antidepressant-like and anxiolytic activity of the polyphenolic extract of Carum carvi L. as well as its...

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Autores principales: Es-safi, Imane, Mechchate, Hamza, Amaghnouje, Amal, Jawhari, Fatima Zahra, Al Kamaly, Omkulthom Mohamed, Imtara, Hamada, Grafov, Andriy, Bari, Amina, Bousta, Dalila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000502/
https://www.ncbi.nlm.nih.gov/pubmed/33807960
http://dx.doi.org/10.3390/life11030207
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author Es-safi, Imane
Mechchate, Hamza
Amaghnouje, Amal
Jawhari, Fatima Zahra
Al Kamaly, Omkulthom Mohamed
Imtara, Hamada
Grafov, Andriy
Bari, Amina
Bousta, Dalila
author_facet Es-safi, Imane
Mechchate, Hamza
Amaghnouje, Amal
Jawhari, Fatima Zahra
Al Kamaly, Omkulthom Mohamed
Imtara, Hamada
Grafov, Andriy
Bari, Amina
Bousta, Dalila
author_sort Es-safi, Imane
collection PubMed
description Depression and anxiety are widespread illnesses whose consequences on patients’ social and professional lives are becoming ever more dangerous and severe. The study’s objective is to explore the antidepressant-like and anxiolytic activity of the polyphenolic extract of Carum carvi L. as well as its antioxidant power as they were recently associated. The predictive antidepressant activity was evaluated using the forced swimming and tail suspension test in mice, a preclinical behavioral model widely used to determine the efficacy of antidepressant drugs. As for anxiolytic-like activity, two models were used, namely the light/dark chamber test to measure the animal’s degree of anxiety and the open field test to evaluate both anxiolytic and locomotor activity. The tests results indicate a remarkable antidepressant and anxiolytic-like effect after oral administration of the polyphenolic fraction of C. carvi and interesting antioxidant property. In the extract it has been confirmed the presence of 6 molecules belonging to polyphenols, identified with HPLC analysis. This study confirms and encourages the traditional use of the extract and appeals to further studies to understand its action mechanism.
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spelling pubmed-80005022021-03-28 An Insight into the Anxiolytic and Antidepressant-Like Proprieties of Carum carvi L. and Their Association with Its Antioxidant Activity Es-safi, Imane Mechchate, Hamza Amaghnouje, Amal Jawhari, Fatima Zahra Al Kamaly, Omkulthom Mohamed Imtara, Hamada Grafov, Andriy Bari, Amina Bousta, Dalila Life (Basel) Article Depression and anxiety are widespread illnesses whose consequences on patients’ social and professional lives are becoming ever more dangerous and severe. The study’s objective is to explore the antidepressant-like and anxiolytic activity of the polyphenolic extract of Carum carvi L. as well as its antioxidant power as they were recently associated. The predictive antidepressant activity was evaluated using the forced swimming and tail suspension test in mice, a preclinical behavioral model widely used to determine the efficacy of antidepressant drugs. As for anxiolytic-like activity, two models were used, namely the light/dark chamber test to measure the animal’s degree of anxiety and the open field test to evaluate both anxiolytic and locomotor activity. The tests results indicate a remarkable antidepressant and anxiolytic-like effect after oral administration of the polyphenolic fraction of C. carvi and interesting antioxidant property. In the extract it has been confirmed the presence of 6 molecules belonging to polyphenols, identified with HPLC analysis. This study confirms and encourages the traditional use of the extract and appeals to further studies to understand its action mechanism. MDPI 2021-03-05 /pmc/articles/PMC8000502/ /pubmed/33807960 http://dx.doi.org/10.3390/life11030207 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Es-safi, Imane
Mechchate, Hamza
Amaghnouje, Amal
Jawhari, Fatima Zahra
Al Kamaly, Omkulthom Mohamed
Imtara, Hamada
Grafov, Andriy
Bari, Amina
Bousta, Dalila
An Insight into the Anxiolytic and Antidepressant-Like Proprieties of Carum carvi L. and Their Association with Its Antioxidant Activity
title An Insight into the Anxiolytic and Antidepressant-Like Proprieties of Carum carvi L. and Their Association with Its Antioxidant Activity
title_full An Insight into the Anxiolytic and Antidepressant-Like Proprieties of Carum carvi L. and Their Association with Its Antioxidant Activity
title_fullStr An Insight into the Anxiolytic and Antidepressant-Like Proprieties of Carum carvi L. and Their Association with Its Antioxidant Activity
title_full_unstemmed An Insight into the Anxiolytic and Antidepressant-Like Proprieties of Carum carvi L. and Their Association with Its Antioxidant Activity
title_short An Insight into the Anxiolytic and Antidepressant-Like Proprieties of Carum carvi L. and Their Association with Its Antioxidant Activity
title_sort insight into the anxiolytic and antidepressant-like proprieties of carum carvi l. and their association with its antioxidant activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000502/
https://www.ncbi.nlm.nih.gov/pubmed/33807960
http://dx.doi.org/10.3390/life11030207
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