JNK signaling prevents biliary cyst formation through a CASPASE-8–dependent function of RIPK1 during aging

The c-Jun N-terminal kinase (JNK) signaling pathway mediates adaptation to stress signals and has been associated with cell death, cell proliferation, and malignant transformation in the liver. However, up to now, its function was experimentally studied mainly in young mice. By generating mice with...

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Detalles Bibliográficos
Autores principales: Müller, Katrin, Honcharova-Biletska, Hanna, Koppe, Christiane, Egger, Michèle, Chan, Lap Kwan, Schneider, Anne T., Küsgens, Lena, Böhm, Friederike, Boege, Yannick, Healy, Marc E., Schmitt, Johannes, Comtesse, Sarah, Castoldi, Mirco, Preisinger, Christian, Szydlowska, Marta, Focaccia, Enrico, Gaisa, Nadine T., Loosen, Sven H., Jörs, Simone, Tacke, Frank, Roderburg, Christoph, Keitel, Verena, Bode, Johannes G., Boor, Peter, Davis, Roger J., Longerich, Thomas, Geisler, Fabian, Heikenwalder, Mathias, Weber, Achim, Vucur, Mihael, Luedde, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000530/
https://www.ncbi.nlm.nih.gov/pubmed/33798093
http://dx.doi.org/10.1073/pnas.2007194118

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