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JNK signaling prevents biliary cyst formation through a CASPASE-8–dependent function of RIPK1 during aging
The c-Jun N-terminal kinase (JNK) signaling pathway mediates adaptation to stress signals and has been associated with cell death, cell proliferation, and malignant transformation in the liver. However, up to now, its function was experimentally studied mainly in young mice. By generating mice with...
Autores principales: | Müller, Katrin, Honcharova-Biletska, Hanna, Koppe, Christiane, Egger, Michèle, Chan, Lap Kwan, Schneider, Anne T., Küsgens, Lena, Böhm, Friederike, Boege, Yannick, Healy, Marc E., Schmitt, Johannes, Comtesse, Sarah, Castoldi, Mirco, Preisinger, Christian, Szydlowska, Marta, Focaccia, Enrico, Gaisa, Nadine T., Loosen, Sven H., Jörs, Simone, Tacke, Frank, Roderburg, Christoph, Keitel, Verena, Bode, Johannes G., Boor, Peter, Davis, Roger J., Longerich, Thomas, Geisler, Fabian, Heikenwalder, Mathias, Weber, Achim, Vucur, Mihael, Luedde, Tom |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000530/ https://www.ncbi.nlm.nih.gov/pubmed/33798093 http://dx.doi.org/10.1073/pnas.2007194118 |
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