Cargando…

Co-Operativity between MYC and BCL-2 Pro-Survival Proteins in Cancer

B-Cell Lymphoma 2 (BCL-2), c-MYC and related proteins are arguably amongst the most widely studied in all of biology. Every year there are thousands of papers reporting on different aspects of their biochemistry, cellular and physiological mechanisms and functions. This plethora of literature can be...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fairlie, Walter Douglas, Lee, Erinna F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000576/ https://www.ncbi.nlm.nih.gov/pubmed/33799592 http://dx.doi.org/10.3390/ijms22062841

Ejemplares similares

Discovery, development and application of drugs targeting BCL-2 pro-survival proteins in cancer
por: Lee, Erinna F., et al.
Publicado: (2021)

Targeting the BCL-2-regulated apoptotic pathway for the treatment of solid cancers
por: Fairlie, W. Douglas, et al.
Publicado: (2021)

The Structural Biology of Bcl-x(L)
por: Lee, Erinna F., et al.
Publicado: (2019)

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival
por: Lee, Erinna F., et al.
Publicado: (2019)

BECLIN1: Protein Structure, Function and Regulation
por: Tran, Sharon, et al.
Publicado: (2021)

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins
por: Mérino, Delphine, et al.
Publicado: (2009)

Structural biology of the intrinsic cell death pathway: what do we know and what is missing?
por: Lee, Erinna F., et al.
Publicado: (2012)

Physiological restraint of Bak by Bcl-x(L) is essential for cell survival
por: Lee, Erinna F., et al.
Publicado: (2016)

Inferior survival in high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements is not associated with MYC/IG gene rearrangements
por: McPhail, Ellen D., et al.
Publicado: (2018)

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer
por: Berger, Stephanie, et al.
Publicado: (2016)

Role and Regulation of Pro-survival BCL-2 Proteins in Multiple Myeloma
por: Slomp, Anne, et al.
Publicado: (2018)

A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma
por: Arulananda, Surein, et al.
Publicado: (2021)

The emerging roles of autophagy in intestinal epithelial cells and its links to inflammatory bowel disease
por: Tran, Sharon, et al.
Publicado: (2023)

Targeting MYC activity in double-hit lymphoma with MYC and BCL2 and/or BCL6 rearrangements with epigenetic bromodomain inhibitors
por: Li, Weiping, et al.
Publicado: (2019)

Clinical Significance of BCL2, C-MYC, and BCL6 Genetic Abnormalities, Epstein-Barr Virus Infection, CD5 Protein Expression, Germinal Center B Cell/Non-Germinal Center B-Cell Subtypes, Co-expression of MYC/BCL2 Proteins and Co-expression of MYC/BCL2/BCL6 Proteins in Diffuse Large B-Cell Lymphoma: A Clinical and Pathological Correlation Study of 120 Patients
por: Ting, Choo-Yuen, et al.
Publicado: (2019)

Molecularly Stratified Treatment Options in Primary Refractory DLBCL/HGBL with MYC and BCL2 or BCL6 Rearrangements (HGBL, NOS with MYC/BCL6)
por: Witte, Hanno M., et al.
Publicado: (2023)

High incidence of MYC and BCL2 abnormalities in mantle cell lymphoma, although only MYC abnormality predicts poor survival
por: Yi, Shuhua, et al.
Publicado: (2015)

MYC overexpression but not MYC/BCL2 double expression predicts survival in bulky mass diffuse large B‐cell lymphoma patients
por: Wang, Yanjie, et al.
Publicado: (2023)

Co-overexpression of bcl-2 and c-myc in uterine cervix carcinomas and premalignant lesions
por: Protrka, Z., et al.
Publicado: (2011)

MYC/BCL2 double- and MYC/BCL2/BCL6 triple-hit follicular lymphomas associated with t(8;14;18)(q24;q32;q21)
por: Takeoka, Kayo, et al.
Publicado: (2022)

Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins
por: Wang, Haolan, et al.
Publicado: (2023)

Domain-specific insight into the recognition of BH3-death motifs by the pro-survival Bcl-2 protein
por: Mushtaq, Ameeq Ul, et al.
Publicado: (2022)

Correction: BCL-XL is an actionable target for treatment of malignant pleural mesothelioma
por: Arulananda, Surein, et al.
Publicado: (2021)

High-Grade B-Cell Lymphoma (HGBL) with MYC and BCL2 and/or BCL6 Rearrangements Is Predominantly BCL6-Rearranged and BCL6-Expressing in Taiwan
por: Tsai, Cheng-Chih, et al.
Publicado: (2021)

Correlation Between C-MYC, BCL-2, and BCL-6 Protein Expression and Gene Translocation as Biomarkers in Diagnosis and Prognosis of Diffuse Large B-cell Lymphoma
por: Zhang, YunXiang, et al.
Publicado: (2019)

Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc
por: Madden, Sarah K., et al.
Publicado: (2021)

Plasmablastic lymphoma with MYC::IGH fusion and BCL2 rearrangement
por: Barouqa, Mohammad, et al.
Publicado: (2022)

Direct visualization of Bcl-2 family protein interactions using live cell fluorescent protein redistribution assays
por: Wong, C, et al.
Publicado: (2012)

Differential Dependence on Beclin 1 for the Regulation of Pro-Survival Autophagy by Bcl-2 and Bcl-xL in HCT116 Colorectal Cancer Cells
por: Priault, Muriel, et al.
Publicado: (2010)

Deuterium Depleted Water Effects on Survival of Lung Cancer Patients and Expression of Kras, Bcl2, and Myc Genes in Mouse Lung
por: Gyöngyi, Zoltán, et al.
Publicado: (2013)

C-MYC, BCL2 and BCL6 Translocation in B-cell Non-Hodgkin Lymphoma Cases
por: Salam, Dayang Sharyati Datu Abdul, et al.
Publicado: (2020)

TdT Positive Lymphoma with MYC, BCL2 and BCL6 Rearrangements: A Review of Diagnosis and Treatment
por: Singh, Aditi, et al.
Publicado: (2022)

BCL-XL is an actionable target for treatment of malignant pleural mesothelioma
por: Arulananda, Surein, et al.
Publicado: (2020)

The Pro-Survival Role of Autophagy Depends on Bcl-2 Under Nutrition Stress Conditions
por: Xu, Hai-Dong, et al.
Publicado: (2013)

Generation of a Murine Model for c-MYC and BCL2 Co-expression B Cell Lymphomas
por: Cai, Zhenming, et al.
Publicado: (2020)

C-MYC and BCL-2 mediate YAP-regulated tumorigenesis in OSCC
por: Chen, Xiyan, et al.
Publicado: (2017)

Targeting BCL2 with venetoclax is a promising therapeutic strategy for “double-proteinexpression” lymphoma with MYC and BCL2 rearrangements
por: Uchida, Akiko, et al.
Publicado: (2019)

P1280: TARGETED INHIBITION OF DHODH IS SYNERGISTIC WITH BCL2 BLOCKADE IN LYMPHOMA WITH CONCURRENT MYC AND BCL2 REARRANGEMENT
por: Mo, W., et al.
Publicado: (2022)

The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL
por: Delbridge, Alex RD, et al.
Publicado: (2017)

Primary cutaneous diffuse large B‐cell lymphoma, leg type with MYC/BCL2/BCL6 overexpression
por: Okada, Yosuke, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3gmln6359ut9mrdon352lajbus