Discovery and Optimization of Selective Inhibitors of Meprin α (Part I)

Meprin α and β are zinc-dependent proteinases implicated in multiple diseases including cancers, fibrosis, and Alzheimer’s. However, until recently, only a few inhibitors of either meprin were reported and no inhibitors are in preclinical development. Moreover, inhibitors of other metzincins develop...

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Detalles Bibliográficos
Autores principales: Hou, Shurong, Diez, Juan, Wang, Chao, Becker-Pauly, Christoph, Fields, Gregg B., Bannister, Thomas, Spicer, Timothy P., Scampavia, Louis D., Minond, Dmitriy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000592/
https://www.ncbi.nlm.nih.gov/pubmed/33671080
http://dx.doi.org/10.3390/ph14030203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000592/
https://www.ncbi.nlm.nih.gov/pubmed/33671080
http://dx.doi.org/10.3390/ph14030203

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