Cargando…

Effect of the Oral Administration of Common Evening Primrose Sprout (Oenothera biennis L.) Extract on Skin Function Improvement in UVB-irradiated Hairless Mice

Most of the studies on common evening primrose (Oenothera biennis L.) are focused on its oils (isolated from seed, root, and stem tissues). We aimed to investigate the effect of the oral administration of OBS-E on the improvement of skin function in skin-damaged hairless mice exposed to excessive ul...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Hoon, Park, Soon Yeong, Chung, Dae Kyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000621/
https://www.ncbi.nlm.nih.gov/pubmed/33800871
http://dx.doi.org/10.3390/ph14030222
_version_ 1783671039642828800
author Kim, Hoon
Park, Soon Yeong
Chung, Dae Kyun
author_facet Kim, Hoon
Park, Soon Yeong
Chung, Dae Kyun
author_sort Kim, Hoon
collection PubMed
description Most of the studies on common evening primrose (Oenothera biennis L.) are focused on its oils (isolated from seed, root, and stem tissues). We aimed to investigate the effect of the oral administration of OBS-E on the improvement of skin function in skin-damaged hairless mice exposed to excessive ultraviolet B (UVB) radiation owing to the preliminary in vitro findings regarding the antioxidant, anti-wrinkle, and skin moisturizing activities of OBS-E. OBS-E administration for 14 weeks did not significantly affect the body weight or clinical signs. Significant reductions were observed in wrinkle parameters (area, number, length, and depth, and metalloproteinase levels) in OBS-E-administered mice compared with those in UVB-irradiated control mice. OBS-E significantly increased skin elasticity and hyaluronic acid content, but it significantly decreased transepidermal water loss. Histomorphometrical analysis revealed that OBS-E significantly reduced the epidermal thickness, area of the collagen-occupied region, and number of microfolds and inflammatory and mast cells. These results demonstrate that OBS-E can effectively enhance skin functions in terms of ameliorating wrinkle formation, promoting skin-moisturization, enhancing skin barrier function, and inhibiting inflammatory reactions. The obtained results provide good starting point for the continuation in the process of developing new inner beauty products based on OBS-E.
format Online
Article
Text
id pubmed-8000621
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-80006212021-03-28 Effect of the Oral Administration of Common Evening Primrose Sprout (Oenothera biennis L.) Extract on Skin Function Improvement in UVB-irradiated Hairless Mice Kim, Hoon Park, Soon Yeong Chung, Dae Kyun Pharmaceuticals (Basel) Article Most of the studies on common evening primrose (Oenothera biennis L.) are focused on its oils (isolated from seed, root, and stem tissues). We aimed to investigate the effect of the oral administration of OBS-E on the improvement of skin function in skin-damaged hairless mice exposed to excessive ultraviolet B (UVB) radiation owing to the preliminary in vitro findings regarding the antioxidant, anti-wrinkle, and skin moisturizing activities of OBS-E. OBS-E administration for 14 weeks did not significantly affect the body weight or clinical signs. Significant reductions were observed in wrinkle parameters (area, number, length, and depth, and metalloproteinase levels) in OBS-E-administered mice compared with those in UVB-irradiated control mice. OBS-E significantly increased skin elasticity and hyaluronic acid content, but it significantly decreased transepidermal water loss. Histomorphometrical analysis revealed that OBS-E significantly reduced the epidermal thickness, area of the collagen-occupied region, and number of microfolds and inflammatory and mast cells. These results demonstrate that OBS-E can effectively enhance skin functions in terms of ameliorating wrinkle formation, promoting skin-moisturization, enhancing skin barrier function, and inhibiting inflammatory reactions. The obtained results provide good starting point for the continuation in the process of developing new inner beauty products based on OBS-E. MDPI 2021-03-06 /pmc/articles/PMC8000621/ /pubmed/33800871 http://dx.doi.org/10.3390/ph14030222 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Kim, Hoon
Park, Soon Yeong
Chung, Dae Kyun
Effect of the Oral Administration of Common Evening Primrose Sprout (Oenothera biennis L.) Extract on Skin Function Improvement in UVB-irradiated Hairless Mice
title Effect of the Oral Administration of Common Evening Primrose Sprout (Oenothera biennis L.) Extract on Skin Function Improvement in UVB-irradiated Hairless Mice
title_full Effect of the Oral Administration of Common Evening Primrose Sprout (Oenothera biennis L.) Extract on Skin Function Improvement in UVB-irradiated Hairless Mice
title_fullStr Effect of the Oral Administration of Common Evening Primrose Sprout (Oenothera biennis L.) Extract on Skin Function Improvement in UVB-irradiated Hairless Mice
title_full_unstemmed Effect of the Oral Administration of Common Evening Primrose Sprout (Oenothera biennis L.) Extract on Skin Function Improvement in UVB-irradiated Hairless Mice
title_short Effect of the Oral Administration of Common Evening Primrose Sprout (Oenothera biennis L.) Extract on Skin Function Improvement in UVB-irradiated Hairless Mice
title_sort effect of the oral administration of common evening primrose sprout (oenothera biennis l.) extract on skin function improvement in uvb-irradiated hairless mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000621/
https://www.ncbi.nlm.nih.gov/pubmed/33800871
http://dx.doi.org/10.3390/ph14030222
work_keys_str_mv AT kimhoon effectoftheoraladministrationofcommoneveningprimrosesproutoenotherabiennislextractonskinfunctionimprovementinuvbirradiatedhairlessmice
AT parksoonyeong effectoftheoraladministrationofcommoneveningprimrosesproutoenotherabiennislextractonskinfunctionimprovementinuvbirradiatedhairlessmice
AT chungdaekyun effectoftheoraladministrationofcommoneveningprimrosesproutoenotherabiennislextractonskinfunctionimprovementinuvbirradiatedhairlessmice