Neuroimaging Correlates of Cognitive Dysfunction in Adults with Multiple Sclerosis

Cognitive impairment is a frequent and meaningful symptom in multiple sclerosis (MS), caused by the accrual of brain structural damage only partially counteracted by effective functional reorganization. As both these aspects can be successfully investigated through the application of advanced neuroi...

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Autores principales: Petracca, Maria, Pontillo, Giuseppe, Moccia, Marcello, Carotenuto, Antonio, Cocozza, Sirio, Lanzillo, Roberta, Brunetti, Arturo, Brescia Morra, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000635/
https://www.ncbi.nlm.nih.gov/pubmed/33803287
http://dx.doi.org/10.3390/brainsci11030346
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author Petracca, Maria
Pontillo, Giuseppe
Moccia, Marcello
Carotenuto, Antonio
Cocozza, Sirio
Lanzillo, Roberta
Brunetti, Arturo
Brescia Morra, Vincenzo
author_facet Petracca, Maria
Pontillo, Giuseppe
Moccia, Marcello
Carotenuto, Antonio
Cocozza, Sirio
Lanzillo, Roberta
Brunetti, Arturo
Brescia Morra, Vincenzo
author_sort Petracca, Maria
collection PubMed
description Cognitive impairment is a frequent and meaningful symptom in multiple sclerosis (MS), caused by the accrual of brain structural damage only partially counteracted by effective functional reorganization. As both these aspects can be successfully investigated through the application of advanced neuroimaging, here, we offer an up-to-date overview of the latest findings on structural, functional and metabolic correlates of cognitive impairment in adults with MS, focusing on the mechanisms sustaining damage accrual and on the identification of useful imaging markers of cognitive decline.
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spelling pubmed-80006352021-03-28 Neuroimaging Correlates of Cognitive Dysfunction in Adults with Multiple Sclerosis Petracca, Maria Pontillo, Giuseppe Moccia, Marcello Carotenuto, Antonio Cocozza, Sirio Lanzillo, Roberta Brunetti, Arturo Brescia Morra, Vincenzo Brain Sci Review Cognitive impairment is a frequent and meaningful symptom in multiple sclerosis (MS), caused by the accrual of brain structural damage only partially counteracted by effective functional reorganization. As both these aspects can be successfully investigated through the application of advanced neuroimaging, here, we offer an up-to-date overview of the latest findings on structural, functional and metabolic correlates of cognitive impairment in adults with MS, focusing on the mechanisms sustaining damage accrual and on the identification of useful imaging markers of cognitive decline. MDPI 2021-03-09 /pmc/articles/PMC8000635/ /pubmed/33803287 http://dx.doi.org/10.3390/brainsci11030346 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Petracca, Maria
Pontillo, Giuseppe
Moccia, Marcello
Carotenuto, Antonio
Cocozza, Sirio
Lanzillo, Roberta
Brunetti, Arturo
Brescia Morra, Vincenzo
Neuroimaging Correlates of Cognitive Dysfunction in Adults with Multiple Sclerosis
title Neuroimaging Correlates of Cognitive Dysfunction in Adults with Multiple Sclerosis
title_full Neuroimaging Correlates of Cognitive Dysfunction in Adults with Multiple Sclerosis
title_fullStr Neuroimaging Correlates of Cognitive Dysfunction in Adults with Multiple Sclerosis
title_full_unstemmed Neuroimaging Correlates of Cognitive Dysfunction in Adults with Multiple Sclerosis
title_short Neuroimaging Correlates of Cognitive Dysfunction in Adults with Multiple Sclerosis
title_sort neuroimaging correlates of cognitive dysfunction in adults with multiple sclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000635/
https://www.ncbi.nlm.nih.gov/pubmed/33803287
http://dx.doi.org/10.3390/brainsci11030346
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