Virological Factors Associated with Failure to the Latest Generation of Direct Acting Agents (DAA) and Re-Treatment Strategy: A Narrative Review

The availability of all oral direct acting antiviral agents (DAAs) has revolutionized the management of HCV infections in recent years, allowing to achieve a sustained virological response (SVR) in more than 95% of cases, irrespective of hepatitis C Virus (HCV) genotype or staging of liver disease....

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Autores principales: Onorato, Lorenzo, Pisaturo, Mariantonietta, Starace, Mario, Minichini, Carmine, Di Fraia, Alessandra, Astorri, Roberta, Coppola, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000640/
https://www.ncbi.nlm.nih.gov/pubmed/33800289
http://dx.doi.org/10.3390/v13030432
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author Onorato, Lorenzo
Pisaturo, Mariantonietta
Starace, Mario
Minichini, Carmine
Di Fraia, Alessandra
Astorri, Roberta
Coppola, Nicola
author_facet Onorato, Lorenzo
Pisaturo, Mariantonietta
Starace, Mario
Minichini, Carmine
Di Fraia, Alessandra
Astorri, Roberta
Coppola, Nicola
author_sort Onorato, Lorenzo
collection PubMed
description The availability of all oral direct acting antiviral agents (DAAs) has revolutionized the management of HCV infections in recent years, allowing to achieve a sustained virological response (SVR) in more than 95% of cases, irrespective of hepatitis C Virus (HCV) genotype or staging of liver disease. Although rare, the failure to the latest-generation regimens (grazoprevir/elbasvir, sofosbuvir/velpatasvir, pibrentasvir/glecaprevir) represents a serious clinical problem, since the data available in the literature on the virological characteristics and management of these patients are few. The aim of the present narrative review was to provide an overview of the impact of baseline RASs in patients treated with the latest-generation DAAs and to analyze the efficacy of the available retreatment strategies in those who have failed these regimens.
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spelling pubmed-80006402021-03-28 Virological Factors Associated with Failure to the Latest Generation of Direct Acting Agents (DAA) and Re-Treatment Strategy: A Narrative Review Onorato, Lorenzo Pisaturo, Mariantonietta Starace, Mario Minichini, Carmine Di Fraia, Alessandra Astorri, Roberta Coppola, Nicola Viruses Review The availability of all oral direct acting antiviral agents (DAAs) has revolutionized the management of HCV infections in recent years, allowing to achieve a sustained virological response (SVR) in more than 95% of cases, irrespective of hepatitis C Virus (HCV) genotype or staging of liver disease. Although rare, the failure to the latest-generation regimens (grazoprevir/elbasvir, sofosbuvir/velpatasvir, pibrentasvir/glecaprevir) represents a serious clinical problem, since the data available in the literature on the virological characteristics and management of these patients are few. The aim of the present narrative review was to provide an overview of the impact of baseline RASs in patients treated with the latest-generation DAAs and to analyze the efficacy of the available retreatment strategies in those who have failed these regimens. MDPI 2021-03-08 /pmc/articles/PMC8000640/ /pubmed/33800289 http://dx.doi.org/10.3390/v13030432 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Onorato, Lorenzo
Pisaturo, Mariantonietta
Starace, Mario
Minichini, Carmine
Di Fraia, Alessandra
Astorri, Roberta
Coppola, Nicola
Virological Factors Associated with Failure to the Latest Generation of Direct Acting Agents (DAA) and Re-Treatment Strategy: A Narrative Review
title Virological Factors Associated with Failure to the Latest Generation of Direct Acting Agents (DAA) and Re-Treatment Strategy: A Narrative Review
title_full Virological Factors Associated with Failure to the Latest Generation of Direct Acting Agents (DAA) and Re-Treatment Strategy: A Narrative Review
title_fullStr Virological Factors Associated with Failure to the Latest Generation of Direct Acting Agents (DAA) and Re-Treatment Strategy: A Narrative Review
title_full_unstemmed Virological Factors Associated with Failure to the Latest Generation of Direct Acting Agents (DAA) and Re-Treatment Strategy: A Narrative Review
title_short Virological Factors Associated with Failure to the Latest Generation of Direct Acting Agents (DAA) and Re-Treatment Strategy: A Narrative Review
title_sort virological factors associated with failure to the latest generation of direct acting agents (daa) and re-treatment strategy: a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000640/
https://www.ncbi.nlm.nih.gov/pubmed/33800289
http://dx.doi.org/10.3390/v13030432
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