Cargando…

Molecular Alterations in Sporadic and SOD1-ALS Immortalized Lymphocytes: Towards a Personalized Therapy

Amyotrophic lateral sclerosis (ALS) is a fatal neurological condition where motor neurons (MNs) degenerate. Most of the ALS cases are sporadic (sALS), whereas 10% are hereditarily transmitted (fALS), among which mutations are found in the gene that codes for the enzyme superoxide dismutase 1 (SOD1)....

Descripción completa

Detalles Bibliográficos
Autores principales:	Lastres-Becker, Isabel, Porras, Gracia, Arribas-Blázquez, Marina, Maestro, Inés, Borrego-Hernández, Daniel, Boya, Patricia, Cerdán, Sebastián, García-Redondo, Alberto, Martínez, Ana, Martin-Requero, Ángeles
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000750/ https://www.ncbi.nlm.nih.gov/pubmed/33809456 http://dx.doi.org/10.3390/ijms22063007

Ejemplares similares

Functional Characterization of a Familial ALS-Associated Missense TBK1 (p-Arg573Gly) Mutation in Patient-Derived Lymphoblasts
por: Porras, Gracia, et al.
Publicado: (2023)

CdSe Quantum Dots in Human Models Derived from ALS Patients: Characterization, Nuclear Penetration Studies and Multiplexing
por: Tosat-Bitrián, Carlota, et al.
Publicado: (2021)

Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis
por: Martín-Cámara, Olmo, et al.
Publicado: (2022)

Aging, NRF2, and TAU: A Perfect Match for Neurodegeneration?
por: Brackhan, Mirjam, et al.
Publicado: (2023)

Role of Resveratrol and Selenium on Oxidative Stress and Expression of Antioxidant and Anti-Aging Genes in Immortalized Lymphocytes from Alzheimer’s Disease Patients
por: Cosín-Tomàs, Marta, et al.
Publicado: (2019)

An emerging role for misfolded wild-type SOD1 in sporadic ALS pathogenesis
por: Rotunno, Melissa S., et al.
Publicado: (2013)

Differential corticospinal tract degeneration in homozygous ‘D90A’ SOD-1 ALS and sporadic ALS
por: Blain, C R V, et al.
Publicado: (2011)

SOD1 oxidation and formation of soluble aggregates in yeast: Relevance to sporadic ALS development
por: Martins, Dorival, et al.
Publicado: (2014)

Novel Antibodies Reveal Inclusions Containing Non-Native SOD1 in Sporadic ALS Patients
por: Forsberg, Karin, et al.
Publicado: (2010)

Oligogenic basis of sporadic ALS: The example of SOD1 p.Ala90Val mutation
por: Kuuluvainen, Liina, et al.
Publicado: (2019)

Familial Alzheimer’s Disease Lymphocytes Respond Differently Than Sporadic Cells to Oxidative Stress: Upregulated p53-p21 Signaling Linked with Presenilin 1 Mutants
por: Wojsiat, Joanna, et al.
Publicado: (2016)

Identity by descent analysis identifies founder events and links SOD1 familial and sporadic ALS cases
por: Henden, Lyndal, et al.
Publicado: (2020)

Misfolded SOD1 pathology in sporadic Amyotrophic Lateral Sclerosis
por: Paré, Bastien, et al.
Publicado: (2018)

Rapid Progression of Sporadic ALS in a Patient Carrying SOD1 p.Gly13Arg Mutation
por: Kim, Myung-Jin, et al.
Publicado: (2016)

Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases
por: Ayers, Jacob I, et al.
Publicado: (2014)

RNA Molecular Signature Profiling in PBMCs of Sporadic ALS Patients: HSP70 Overexpression Is Associated with Nuclear SOD1
por: Garofalo, Maria, et al.
Publicado: (2022)

Immortalization of human lymphocytes by Epstein-Barr virus.
por: Miller, G.
Publicado: (1982)

Discovery of Mitophagy Inhibitors with Therapeutic Potential in Different Familial Amyotrophic Lateral Sclerosis Mutations
por: Maestro, Ines, et al.
Publicado: (2022)

Tideglusib, a Non-ATP Competitive Inhibitor of GSK-3β as a Drug Candidate for the Treatment of Amyotrophic Lateral Sclerosis
por: Martínez-González, Loreto, et al.
Publicado: (2021)

Special Issue “Role of NRF2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches”
por: Lastres-Becker, Isabel
Publicado: (2021)

Editorial: Tau Protein: Mechanisms From Health to Degeneration
por: Lastres-Becker, Isabel
Publicado: (2021)

Special Issue “Role of NRF2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches II”
por: Lastres-Becker, Isabel
Publicado: (2023)

Altered Intracellular Localization of SOD1 in Leukocytes from Patients with Sporadic Amyotrophic Lateral Sclerosis
por: Cereda, Cristina, et al.
Publicado: (2013)

Establishment and characterization of HBV-associated B lymphocytes with an immortalization potential
por: Qi, Xiaoying, et al.
Publicado: (2019)

A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity
por: Joyce, Peter I., et al.
Publicado: (2015)

Genetic Biomarkers for ALS Disease in Transgenic SOD1(G93A) Mice
por: Calvo, Ana C., et al.
Publicado: (2012)

Immortalization of human lymphocytes by fusion with cytoplasts of transformed mouse L cells
Publicado: (1986)

Immortalized Parkinson's disease lymphocytes have enhanced mitochondrial respiratory activity
por: Annesley, Sarah J., et al.
Publicado: (2016)

An examination of wild-type SOD1 in modulating the toxicity and aggregation of ALS-associated mutant SOD1
por: Prudencio, Mercedes, et al.
Publicado: (2010)

Cytotoxic CD8(+) T lymphocytes expressing ALS-causing SOD1 mutant selectively trigger death of spinal motoneurons
por: Coque, Emmanuelle, et al.
Publicado: (2019)

Immortality
por: Carroll, John
Publicado: (2020)

Genetic screening in sporadic ALS and FTD
por: Turner, Martin R, et al.
Publicado: (2017)

S-acylation of SOD1, CCS, and a stable SOD1-CCS heterodimer in human spinal cords from ALS and non-ALS subjects
por: Antinone, Sarah E., et al.
Publicado: (2017)

Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models
por: Brasil, Aline A., et al.
Publicado: (2017)

Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy
por: Cuadrado, Antonio, et al.
Publicado: (2017)

Neutrophil-to-lymphocyte ratio in sporadic amyotrophic lateral sclerosis
por: Wei, Qian-Qian, et al.
Publicado: (2021)

Better survival in female SOD1-mutant patients with ALS: a study of SOD1-related natural history
por: Tang, Lu, et al.
Publicado: (2019)

ER stress links aging to sporadic ALS
por: Medinas, Danilo B., et al.
Publicado: (2019)

De novo mutations in SOD1 are a cause of ALS
por: Müller, Kathrin, et al.
Publicado: (2022)

A Synthetic SOD/Catalase Mimic Compound for the Treatment of ALS
por: Soll, Matan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_v3je6a02j3vqvp3q4tbtuue8ap