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Validation of an LC-MS/MS Method to Quantify the New TRPC6 Inhibitor SH045 (Larixyl N-methylcarbamate) and Its Application in an Exploratory Pharmacokinetic Study in Mice

TRPC6 (transient receptor potential cation channels; canonical subfamily C, member 6) is widespread localized in mammalian tissues like kidney and lung and associated with progressive proteinuria and pathophysiological pulmonary alterations, e.g., reperfusion edema or lung fibrosis. However, the und...

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Detalles Bibliográficos
Autores principales:	Chai, Xiao-Ning, Ludwig, Friedrich-Alexander, Müglitz, Anne, Schaefer, Michael, Yin, Hai-Yan, Brust, Peter, Regenthal, Ralf, Krügel, Ute
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000919/ https://www.ncbi.nlm.nih.gov/pubmed/33805686 http://dx.doi.org/10.3390/ph14030259

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