Potential Genetic Contributions of the Central Nervous System to a Predisposition to Elite Athletic Traits: State-of-the-Art and Future Perspectives

Recent remarkable advances in genetic technologies have allowed for the identification of genetic factors potentially related to a predisposition to elite athletic performance. Most of these genetic variants seem to be implicated in musculoskeletal and cardiopulmonary functions. Conversely, it remai...

Descripción completa

Detalles Bibliográficos
Autores principales: Kitazawa, Hiroya, Hasegawa, Kazuya, Aruga, Daichi, Tanaka, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000928/
https://www.ncbi.nlm.nih.gov/pubmed/33807752
http://dx.doi.org/10.3390/genes12030371
_version_ 1783671110887276544
author Kitazawa, Hiroya
Hasegawa, Kazuya
Aruga, Daichi
Tanaka, Masashi
author_facet Kitazawa, Hiroya
Hasegawa, Kazuya
Aruga, Daichi
Tanaka, Masashi
author_sort Kitazawa, Hiroya
collection PubMed
description Recent remarkable advances in genetic technologies have allowed for the identification of genetic factors potentially related to a predisposition to elite athletic performance. Most of these genetic variants seem to be implicated in musculoskeletal and cardiopulmonary functions. Conversely, it remains unclear whether functions of the central nervous system (CNS) genetically contribute to elite athletic traits, although the CNS plays critical roles in exercise performance. Accumulating evidence has highlighted the emerging implications of CNS-related genes in the modulation of brain activities, including mental performance and motor-related traits, thereby potentially contributing to high levels of exercise performance. In this review, recent advances are summarized, and future research directions are discussed in regard to CNS-related genes with potential roles in a predisposition to elite athletic traits.
format Online
Article
Text
id pubmed-8000928
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-80009282021-03-28 Potential Genetic Contributions of the Central Nervous System to a Predisposition to Elite Athletic Traits: State-of-the-Art and Future Perspectives Kitazawa, Hiroya Hasegawa, Kazuya Aruga, Daichi Tanaka, Masashi Genes (Basel) Review Recent remarkable advances in genetic technologies have allowed for the identification of genetic factors potentially related to a predisposition to elite athletic performance. Most of these genetic variants seem to be implicated in musculoskeletal and cardiopulmonary functions. Conversely, it remains unclear whether functions of the central nervous system (CNS) genetically contribute to elite athletic traits, although the CNS plays critical roles in exercise performance. Accumulating evidence has highlighted the emerging implications of CNS-related genes in the modulation of brain activities, including mental performance and motor-related traits, thereby potentially contributing to high levels of exercise performance. In this review, recent advances are summarized, and future research directions are discussed in regard to CNS-related genes with potential roles in a predisposition to elite athletic traits. MDPI 2021-03-05 /pmc/articles/PMC8000928/ /pubmed/33807752 http://dx.doi.org/10.3390/genes12030371 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Kitazawa, Hiroya
Hasegawa, Kazuya
Aruga, Daichi
Tanaka, Masashi
Potential Genetic Contributions of the Central Nervous System to a Predisposition to Elite Athletic Traits: State-of-the-Art and Future Perspectives
title Potential Genetic Contributions of the Central Nervous System to a Predisposition to Elite Athletic Traits: State-of-the-Art and Future Perspectives
title_full Potential Genetic Contributions of the Central Nervous System to a Predisposition to Elite Athletic Traits: State-of-the-Art and Future Perspectives
title_fullStr Potential Genetic Contributions of the Central Nervous System to a Predisposition to Elite Athletic Traits: State-of-the-Art and Future Perspectives
title_full_unstemmed Potential Genetic Contributions of the Central Nervous System to a Predisposition to Elite Athletic Traits: State-of-the-Art and Future Perspectives
title_short Potential Genetic Contributions of the Central Nervous System to a Predisposition to Elite Athletic Traits: State-of-the-Art and Future Perspectives
title_sort potential genetic contributions of the central nervous system to a predisposition to elite athletic traits: state-of-the-art and future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000928/
https://www.ncbi.nlm.nih.gov/pubmed/33807752
http://dx.doi.org/10.3390/genes12030371
work_keys_str_mv AT kitazawahiroya potentialgeneticcontributionsofthecentralnervoussystemtoapredispositiontoeliteathletictraitsstateoftheartandfutureperspectives
AT hasegawakazuya potentialgeneticcontributionsofthecentralnervoussystemtoapredispositiontoeliteathletictraitsstateoftheartandfutureperspectives
AT arugadaichi potentialgeneticcontributionsofthecentralnervoussystemtoapredispositiontoeliteathletictraitsstateoftheartandfutureperspectives
AT tanakamasashi potentialgeneticcontributionsofthecentralnervoussystemtoapredispositiontoeliteathletictraitsstateoftheartandfutureperspectives

Ejemplares similares