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Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment

Pancreatic cancer is the most lethal solid malignancy, and the number of patients with pancreatic cancer is increasing. Systemic chemotherapies are often ineffective for such patients, and there is an urgent need for personalized medicine. Unlike other types of cancer, personalized treatments for pa...

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Autores principales: Iwasaki, Eisuke, Fukuhara, Seiichiro, Horibe, Masayasu, Kawasaki, Shintaro, Seino, Takashi, Takimoto, Yoichi, Tamagawa, Hiroki, Machida, Yujiro, Kayashima, Atsuto, Noda, Marin, Hayashi, Hideyuki, Kanai, Takanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000964/
https://www.ncbi.nlm.nih.gov/pubmed/33800161
http://dx.doi.org/10.3390/diagnostics11030469
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author Iwasaki, Eisuke
Fukuhara, Seiichiro
Horibe, Masayasu
Kawasaki, Shintaro
Seino, Takashi
Takimoto, Yoichi
Tamagawa, Hiroki
Machida, Yujiro
Kayashima, Atsuto
Noda, Marin
Hayashi, Hideyuki
Kanai, Takanori
author_facet Iwasaki, Eisuke
Fukuhara, Seiichiro
Horibe, Masayasu
Kawasaki, Shintaro
Seino, Takashi
Takimoto, Yoichi
Tamagawa, Hiroki
Machida, Yujiro
Kayashima, Atsuto
Noda, Marin
Hayashi, Hideyuki
Kanai, Takanori
author_sort Iwasaki, Eisuke
collection PubMed
description Pancreatic cancer is the most lethal solid malignancy, and the number of patients with pancreatic cancer is increasing. Systemic chemotherapies are often ineffective for such patients, and there is an urgent need for personalized medicine. Unlike other types of cancer, personalized treatments for pancreatic cancer are still in development. Consequently, pancreatic cancer is less sensitive to anticancer drugs and is often refractory to common treatments. Therefore, advances in personalized medicine for pancreatic cancer are necessary. This review examined advances in personalized medicine for pancreatic cancer, including the use of endoscopic ultrasound (EUS)-guided sampling. EUS-guided sampling is widely used for diagnosing pancreatic tumors and is expected to be applied to sampled tissues. Additionally, there has been an increase in clinical research using EUS-guided sampling. The combination of precision medicine using genomic testing and pharmacological profiles based on high-throughput drug sensitivity testing using patient-derived organoids is expected to revolutionize pancreatic cancer treatment.
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spelling pubmed-80009642021-03-28 Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment Iwasaki, Eisuke Fukuhara, Seiichiro Horibe, Masayasu Kawasaki, Shintaro Seino, Takashi Takimoto, Yoichi Tamagawa, Hiroki Machida, Yujiro Kayashima, Atsuto Noda, Marin Hayashi, Hideyuki Kanai, Takanori Diagnostics (Basel) Review Pancreatic cancer is the most lethal solid malignancy, and the number of patients with pancreatic cancer is increasing. Systemic chemotherapies are often ineffective for such patients, and there is an urgent need for personalized medicine. Unlike other types of cancer, personalized treatments for pancreatic cancer are still in development. Consequently, pancreatic cancer is less sensitive to anticancer drugs and is often refractory to common treatments. Therefore, advances in personalized medicine for pancreatic cancer are necessary. This review examined advances in personalized medicine for pancreatic cancer, including the use of endoscopic ultrasound (EUS)-guided sampling. EUS-guided sampling is widely used for diagnosing pancreatic tumors and is expected to be applied to sampled tissues. Additionally, there has been an increase in clinical research using EUS-guided sampling. The combination of precision medicine using genomic testing and pharmacological profiles based on high-throughput drug sensitivity testing using patient-derived organoids is expected to revolutionize pancreatic cancer treatment. MDPI 2021-03-08 /pmc/articles/PMC8000964/ /pubmed/33800161 http://dx.doi.org/10.3390/diagnostics11030469 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Iwasaki, Eisuke
Fukuhara, Seiichiro
Horibe, Masayasu
Kawasaki, Shintaro
Seino, Takashi
Takimoto, Yoichi
Tamagawa, Hiroki
Machida, Yujiro
Kayashima, Atsuto
Noda, Marin
Hayashi, Hideyuki
Kanai, Takanori
Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment
title Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment
title_full Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment
title_fullStr Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment
title_full_unstemmed Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment
title_short Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment
title_sort endoscopic ultrasound-guided sampling for personalized pancreatic cancer treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000964/
https://www.ncbi.nlm.nih.gov/pubmed/33800161
http://dx.doi.org/10.3390/diagnostics11030469
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