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Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment
Pancreatic cancer is the most lethal solid malignancy, and the number of patients with pancreatic cancer is increasing. Systemic chemotherapies are often ineffective for such patients, and there is an urgent need for personalized medicine. Unlike other types of cancer, personalized treatments for pa...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000964/ https://www.ncbi.nlm.nih.gov/pubmed/33800161 http://dx.doi.org/10.3390/diagnostics11030469 |
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author | Iwasaki, Eisuke Fukuhara, Seiichiro Horibe, Masayasu Kawasaki, Shintaro Seino, Takashi Takimoto, Yoichi Tamagawa, Hiroki Machida, Yujiro Kayashima, Atsuto Noda, Marin Hayashi, Hideyuki Kanai, Takanori |
author_facet | Iwasaki, Eisuke Fukuhara, Seiichiro Horibe, Masayasu Kawasaki, Shintaro Seino, Takashi Takimoto, Yoichi Tamagawa, Hiroki Machida, Yujiro Kayashima, Atsuto Noda, Marin Hayashi, Hideyuki Kanai, Takanori |
author_sort | Iwasaki, Eisuke |
collection | PubMed |
description | Pancreatic cancer is the most lethal solid malignancy, and the number of patients with pancreatic cancer is increasing. Systemic chemotherapies are often ineffective for such patients, and there is an urgent need for personalized medicine. Unlike other types of cancer, personalized treatments for pancreatic cancer are still in development. Consequently, pancreatic cancer is less sensitive to anticancer drugs and is often refractory to common treatments. Therefore, advances in personalized medicine for pancreatic cancer are necessary. This review examined advances in personalized medicine for pancreatic cancer, including the use of endoscopic ultrasound (EUS)-guided sampling. EUS-guided sampling is widely used for diagnosing pancreatic tumors and is expected to be applied to sampled tissues. Additionally, there has been an increase in clinical research using EUS-guided sampling. The combination of precision medicine using genomic testing and pharmacological profiles based on high-throughput drug sensitivity testing using patient-derived organoids is expected to revolutionize pancreatic cancer treatment. |
format | Online Article Text |
id | pubmed-8000964 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80009642021-03-28 Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment Iwasaki, Eisuke Fukuhara, Seiichiro Horibe, Masayasu Kawasaki, Shintaro Seino, Takashi Takimoto, Yoichi Tamagawa, Hiroki Machida, Yujiro Kayashima, Atsuto Noda, Marin Hayashi, Hideyuki Kanai, Takanori Diagnostics (Basel) Review Pancreatic cancer is the most lethal solid malignancy, and the number of patients with pancreatic cancer is increasing. Systemic chemotherapies are often ineffective for such patients, and there is an urgent need for personalized medicine. Unlike other types of cancer, personalized treatments for pancreatic cancer are still in development. Consequently, pancreatic cancer is less sensitive to anticancer drugs and is often refractory to common treatments. Therefore, advances in personalized medicine for pancreatic cancer are necessary. This review examined advances in personalized medicine for pancreatic cancer, including the use of endoscopic ultrasound (EUS)-guided sampling. EUS-guided sampling is widely used for diagnosing pancreatic tumors and is expected to be applied to sampled tissues. Additionally, there has been an increase in clinical research using EUS-guided sampling. The combination of precision medicine using genomic testing and pharmacological profiles based on high-throughput drug sensitivity testing using patient-derived organoids is expected to revolutionize pancreatic cancer treatment. MDPI 2021-03-08 /pmc/articles/PMC8000964/ /pubmed/33800161 http://dx.doi.org/10.3390/diagnostics11030469 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Review Iwasaki, Eisuke Fukuhara, Seiichiro Horibe, Masayasu Kawasaki, Shintaro Seino, Takashi Takimoto, Yoichi Tamagawa, Hiroki Machida, Yujiro Kayashima, Atsuto Noda, Marin Hayashi, Hideyuki Kanai, Takanori Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment |
title | Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment |
title_full | Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment |
title_fullStr | Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment |
title_full_unstemmed | Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment |
title_short | Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment |
title_sort | endoscopic ultrasound-guided sampling for personalized pancreatic cancer treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000964/ https://www.ncbi.nlm.nih.gov/pubmed/33800161 http://dx.doi.org/10.3390/diagnostics11030469 |
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