The Development and Optimization of Hot-Melt Extruded Amorphous Solid Dispersions Containing Rivaroxaban in Combination with Polymers

Rivaroxaban (RXB), a novel oral anticoagulant that directly inhibits factor Xa, is a poorly soluble drug belonging to Biopharmaceutics Classification System (BCS) class II. In this study, a hot-melt extruded amorphous solid dispersion (HME-ASD) containing RXB is prepared by changing the drug:polymer...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Jong-Hwa, Jeong, Hyeong Sik, Jeong, Jong-Woo, Koo, Tae-Sung, Kim, Do-Kyun, Cho, Young Ho, Lee, Gye Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001048/
https://www.ncbi.nlm.nih.gov/pubmed/33800741
http://dx.doi.org/10.3390/pharmaceutics13030344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001048/
https://www.ncbi.nlm.nih.gov/pubmed/33800741
http://dx.doi.org/10.3390/pharmaceutics13030344

Ejemplares similares