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Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease
Advanced age is the greatest risk factor for aging-related brain disorders including Alzheimer’s disease (AD). However, the detailed mechanisms that mechanistically link aging and AD remain elusive. In recent years, a mitochondrial hypothesis of brain aging and AD has been accentuated. Mitochondrial...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001058/ https://www.ncbi.nlm.nih.gov/pubmed/33804048 http://dx.doi.org/10.3390/cells10030649 |
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author | Jia, Kun Du, Heng |
author_facet | Jia, Kun Du, Heng |
author_sort | Jia, Kun |
collection | PubMed |
description | Advanced age is the greatest risk factor for aging-related brain disorders including Alzheimer’s disease (AD). However, the detailed mechanisms that mechanistically link aging and AD remain elusive. In recent years, a mitochondrial hypothesis of brain aging and AD has been accentuated. Mitochondrial permeability transition pore (mPTP) is a mitochondrial response to intramitochondrial and intracellular stresses. mPTP overactivation has been implicated in mitochondrial dysfunction in aging and AD brains. This review summarizes the up-to-date progress in the study of mPTP in aging and AD and attempts to establish a link between brain aging and AD from a perspective of mPTP-mediated mitochondrial dysfunction. |
format | Online Article Text |
id | pubmed-8001058 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80010582021-03-28 Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease Jia, Kun Du, Heng Cells Review Advanced age is the greatest risk factor for aging-related brain disorders including Alzheimer’s disease (AD). However, the detailed mechanisms that mechanistically link aging and AD remain elusive. In recent years, a mitochondrial hypothesis of brain aging and AD has been accentuated. Mitochondrial permeability transition pore (mPTP) is a mitochondrial response to intramitochondrial and intracellular stresses. mPTP overactivation has been implicated in mitochondrial dysfunction in aging and AD brains. This review summarizes the up-to-date progress in the study of mPTP in aging and AD and attempts to establish a link between brain aging and AD from a perspective of mPTP-mediated mitochondrial dysfunction. MDPI 2021-03-15 /pmc/articles/PMC8001058/ /pubmed/33804048 http://dx.doi.org/10.3390/cells10030649 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Review Jia, Kun Du, Heng Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease |
title | Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease |
title_full | Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease |
title_fullStr | Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease |
title_full_unstemmed | Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease |
title_short | Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease |
title_sort | mitochondrial permeability transition: a pore intertwines brain aging and alzheimer’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001058/ https://www.ncbi.nlm.nih.gov/pubmed/33804048 http://dx.doi.org/10.3390/cells10030649 |
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