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Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease

Advanced age is the greatest risk factor for aging-related brain disorders including Alzheimer’s disease (AD). However, the detailed mechanisms that mechanistically link aging and AD remain elusive. In recent years, a mitochondrial hypothesis of brain aging and AD has been accentuated. Mitochondrial...

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Detalles Bibliográficos
Autores principales: Jia, Kun, Du, Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001058/
https://www.ncbi.nlm.nih.gov/pubmed/33804048
http://dx.doi.org/10.3390/cells10030649
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author Jia, Kun
Du, Heng
author_facet Jia, Kun
Du, Heng
author_sort Jia, Kun
collection PubMed
description Advanced age is the greatest risk factor for aging-related brain disorders including Alzheimer’s disease (AD). However, the detailed mechanisms that mechanistically link aging and AD remain elusive. In recent years, a mitochondrial hypothesis of brain aging and AD has been accentuated. Mitochondrial permeability transition pore (mPTP) is a mitochondrial response to intramitochondrial and intracellular stresses. mPTP overactivation has been implicated in mitochondrial dysfunction in aging and AD brains. This review summarizes the up-to-date progress in the study of mPTP in aging and AD and attempts to establish a link between brain aging and AD from a perspective of mPTP-mediated mitochondrial dysfunction.
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spelling pubmed-80010582021-03-28 Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease Jia, Kun Du, Heng Cells Review Advanced age is the greatest risk factor for aging-related brain disorders including Alzheimer’s disease (AD). However, the detailed mechanisms that mechanistically link aging and AD remain elusive. In recent years, a mitochondrial hypothesis of brain aging and AD has been accentuated. Mitochondrial permeability transition pore (mPTP) is a mitochondrial response to intramitochondrial and intracellular stresses. mPTP overactivation has been implicated in mitochondrial dysfunction in aging and AD brains. This review summarizes the up-to-date progress in the study of mPTP in aging and AD and attempts to establish a link between brain aging and AD from a perspective of mPTP-mediated mitochondrial dysfunction. MDPI 2021-03-15 /pmc/articles/PMC8001058/ /pubmed/33804048 http://dx.doi.org/10.3390/cells10030649 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Jia, Kun
Du, Heng
Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease
title Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease
title_full Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease
title_fullStr Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease
title_full_unstemmed Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease
title_short Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease
title_sort mitochondrial permeability transition: a pore intertwines brain aging and alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001058/
https://www.ncbi.nlm.nih.gov/pubmed/33804048
http://dx.doi.org/10.3390/cells10030649
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