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The Composition and Diversity of the Gut Microbiota in Children Is Modifiable by the Household Dogs: Impact of a Canine-Specific Probiotic

The development of the infant gut microbiota is initiated during pregnancy and continued through early life and childhood, guided by the immediate environment of the child. Our aim was to characterize the shared microbiota between dogs and children as well as to determine whether introduction to dog...

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Autores principales: Gómez-Gallego, Carlos, Forsgren, Mira, Selma-Royo, Marta, Nermes, Merja, Collado, Maria Carmen, Salminen, Seppo, Beasley, Shea, Isolauri, Erika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001081/
https://www.ncbi.nlm.nih.gov/pubmed/33800493
http://dx.doi.org/10.3390/microorganisms9030557
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author Gómez-Gallego, Carlos
Forsgren, Mira
Selma-Royo, Marta
Nermes, Merja
Collado, Maria Carmen
Salminen, Seppo
Beasley, Shea
Isolauri, Erika
author_facet Gómez-Gallego, Carlos
Forsgren, Mira
Selma-Royo, Marta
Nermes, Merja
Collado, Maria Carmen
Salminen, Seppo
Beasley, Shea
Isolauri, Erika
author_sort Gómez-Gallego, Carlos
collection PubMed
description The development of the infant gut microbiota is initiated during pregnancy and continued through early life and childhood, guided by the immediate environment of the child. Our aim was to characterize the shared microbiota between dogs and children as well as to determine whether introduction to dogs of a dog-specific probiotic combination modifies the transfer process. We studied 31 children from allergic families with pet dog(s) and 18 control families without a dog. Altogether 37 dogs were randomized for a 4-week period in a double-blind design to receive canine-derived probiotic product containing a mixture of L. fermentum, L. plantarum, and L. rhamnosus, or placebo. Fecal samples from children and dogs were taken before and after the treatment. Distinctive gut microbiota composition was observed in children with dogs compared to those without a dog, characterized by higher abundance of Bacteroides and short-chain fatty acid producing bacteria such as Ruminococcus and Lachnospiraceae. Probiotic intervention in dogs had an impact on the composition of the gut microbiota in both dogs and children, characterized by a reduction in Bacteroides. We provide evidence for a direct effect of home environment and household pets on children microbiota and document that modification of dog microbiota by specific probiotics is reflected in children’s microbiota.
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spelling pubmed-80010812021-03-28 The Composition and Diversity of the Gut Microbiota in Children Is Modifiable by the Household Dogs: Impact of a Canine-Specific Probiotic Gómez-Gallego, Carlos Forsgren, Mira Selma-Royo, Marta Nermes, Merja Collado, Maria Carmen Salminen, Seppo Beasley, Shea Isolauri, Erika Microorganisms Article The development of the infant gut microbiota is initiated during pregnancy and continued through early life and childhood, guided by the immediate environment of the child. Our aim was to characterize the shared microbiota between dogs and children as well as to determine whether introduction to dogs of a dog-specific probiotic combination modifies the transfer process. We studied 31 children from allergic families with pet dog(s) and 18 control families without a dog. Altogether 37 dogs were randomized for a 4-week period in a double-blind design to receive canine-derived probiotic product containing a mixture of L. fermentum, L. plantarum, and L. rhamnosus, or placebo. Fecal samples from children and dogs were taken before and after the treatment. Distinctive gut microbiota composition was observed in children with dogs compared to those without a dog, characterized by higher abundance of Bacteroides and short-chain fatty acid producing bacteria such as Ruminococcus and Lachnospiraceae. Probiotic intervention in dogs had an impact on the composition of the gut microbiota in both dogs and children, characterized by a reduction in Bacteroides. We provide evidence for a direct effect of home environment and household pets on children microbiota and document that modification of dog microbiota by specific probiotics is reflected in children’s microbiota. MDPI 2021-03-08 /pmc/articles/PMC8001081/ /pubmed/33800493 http://dx.doi.org/10.3390/microorganisms9030557 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Gómez-Gallego, Carlos
Forsgren, Mira
Selma-Royo, Marta
Nermes, Merja
Collado, Maria Carmen
Salminen, Seppo
Beasley, Shea
Isolauri, Erika
The Composition and Diversity of the Gut Microbiota in Children Is Modifiable by the Household Dogs: Impact of a Canine-Specific Probiotic
title The Composition and Diversity of the Gut Microbiota in Children Is Modifiable by the Household Dogs: Impact of a Canine-Specific Probiotic
title_full The Composition and Diversity of the Gut Microbiota in Children Is Modifiable by the Household Dogs: Impact of a Canine-Specific Probiotic
title_fullStr The Composition and Diversity of the Gut Microbiota in Children Is Modifiable by the Household Dogs: Impact of a Canine-Specific Probiotic
title_full_unstemmed The Composition and Diversity of the Gut Microbiota in Children Is Modifiable by the Household Dogs: Impact of a Canine-Specific Probiotic
title_short The Composition and Diversity of the Gut Microbiota in Children Is Modifiable by the Household Dogs: Impact of a Canine-Specific Probiotic
title_sort composition and diversity of the gut microbiota in children is modifiable by the household dogs: impact of a canine-specific probiotic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001081/
https://www.ncbi.nlm.nih.gov/pubmed/33800493
http://dx.doi.org/10.3390/microorganisms9030557
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