Cargando…

Repurposing of Some Natural Product Isolates as SARS-COV-2 Main Protease Inhibitors via In Vitro Cell Free and Cell-Based Antiviral Assessments and Molecular Modeling Approaches

The emergence of the SARS-CoV-2 pandemic has prompted scientists to search for an efficient antiviral medicine to overcome the rapid spread and the marked increase in the number of patients worldwide. In this regard natural products could be a potential source of substances active against coronaviru...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abdallah, Hossam M., El-Halawany, Ali M., Sirwi, Alaa, El-Araby, Amr M., Mohamed, Gamal A., Ibrahim, Sabrin R. M., Koshak, Abdulrahman E., Asfour, Hani Z., Awan, Zuhier A., A. Elfaky, Mahmoud
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001104/ https://www.ncbi.nlm.nih.gov/pubmed/33806331 http://dx.doi.org/10.3390/ph14030213

Ejemplares similares

Bio-Guided Isolation of SARS-CoV-2 Main Protease Inhibitors from Medicinal Plants: In Vitro Assay and Molecular Dynamics
por: Abdallah, Hossam M., et al.
Publicado: (2022)

Bioassay Guided Isolation and Docking Studies of a Potential β-Lactamase Inhibitor from Clutia myricoides
por: Elfaky, Mahmoud A., et al.
Publicado: (2020)

Terretonin as a New Protective Agent against Sepsis-Induced Acute Lung Injury: Impact on SIRT1/Nrf2/NF-κBp65/NLRP3 Signaling
por: Mohamed, Gamal A., et al.
Publicado: (2021)

Umuhengerin Neuroprotective Effects in Streptozotocin-Induced Alzheimer’s Disease Mouse Model via Targeting Nrf2 and NF-Kβ Signaling Cascades
por: Sirwi, Alaa, et al.
Publicado: (2021)

Cepabiflas B and C as Novel Anti-Inflammatory and Anti-Apoptotic Agents against Endotoxin-Induced Acute Kidney and Hepatic Injury in Mice: Impact on Bax/Bcl2 and Nrf2/NF-κB Signalling Pathways
por: Rizq, Akaber T., et al.
Publicado: (2023)

SIRT1/Nrf2/NF-κB Signaling Mediates Anti-Inflammatory and Anti-Apoptotic Activities of Oleanolic Acid in a Mouse Model of Acute Hepatorenal Damage
por: Alqrad, Manea A. I., et al.
Publicado: (2023)

Large-Scale Production of Bioactive Terrein by Aspergillus terreus Strain S020 Isolated from the Saudi Coast of the Red Sea
por: Asfour, Hani Z., et al.
Publicado: (2019)

Synthetic bulky NS4A peptide variants bind to and inhibit HCV NS3 protease
por: El-Araby, Moustafa E., et al.
Publicado: (2020)

Mangostanaxanthone IV Ameliorates Streptozotocin-Induced Neuro-Inflammation, Amyloid Deposition, and Tau Hyperphosphorylation via Modulating PI3K/Akt/GSK-3β Pathway
por: Abdallah, Hossam M., et al.
Publicado: (2021)

Mokko Lactone Alleviates Doxorubicin-Induced Cardiotoxicity in Rats via Antioxidant, Anti-Inflammatory, and Antiapoptotic Activities
por: Sirwi, Alaa, et al.
Publicado: (2022)

1H-Imidazole-2,5-Dicarboxamides as NS4A Peptidomimetics: Identification of a New Approach to Inhibit HCV-NS3 Protease
por: Omar, Abdelsattar M., et al.
Publicado: (2020)

Phenolics from Chrozophora oblongifolia Aerial Parts as Inhibitors of α-Glucosidases and Advanced Glycation End Products: In-Vitro Assessment, Molecular Docking and Dynamics Studies
por: Abdallah, Hossam M., et al.
Publicado: (2022)

Drug repurposing for SARS-CoV-2 main protease: Molecular docking and molecular dynamics investigations
por: Omer, Samia E., et al.
Publicado: (2022)

Mokko Lactone Attenuates Doxorubicin-Induced Hepatotoxicity in Rats: Emphasis on Sirt-1/FOXO1/NF-κB Axis
por: Sirwi, Alaa, et al.
Publicado: (2021)

Repurposing of renin inhibitors as SARS-COV-2 main protease inhibitors: A computational study
por: Refaey, Rana H., et al.
Publicado: (2021)

Summary of Natural Products Ameliorate Concanavalin A-Induced Liver Injury: Structures, Sources, Pharmacological Effects, and Mechanisms of Action
por: Ibrahim, Sabrin R. M., et al.
Publicado: (2021)

Fungal Depsides—Naturally Inspiring Molecules: Biosynthesis, Structural Characterization, and Biological Activities
por: Ibrahim, Sabrin R. M., et al.
Publicado: (2021)

Bright Side of Fusarium oxysporum: Secondary Metabolites Bioactivities and Industrial Relevance in Biotechnology and Nanotechnology
por: Ibrahim, Sabrin R. M., et al.
Publicado: (2021)

Impact of Drug Repurposing on SARS-Cov-2 Main Protease
por: Ndagi, Umar, et al.
Publicado: (2023)

Natural Reno-Protective Agents against Cyclosporine A-Induced Nephrotoxicity: An Overview
por: Ibrahim, Sabrin R. M., et al.
Publicado: (2022)

Nitric-Oxide-Mediated Vasodilation of Bioactive Compounds Isolated from Hypericum revolutum in Rat Aorta
por: Abdallah, Hossam M., et al.
Publicado: (2021)

Taif Rose Oil Ameliorates UVB-Induced Oxidative Damage and Skin Photoaging in Rats via Modulation of MAPK and MMP Signaling Pathways
por: Abdallah, Hossam M., et al.
Publicado: (2023)

Phenolics from Garcinia mangostana Inhibit Advanced Glycation Endproducts Formation: Effect on Amadori Products, Cross-Linked Structures and Protein Thiols
por: Abdallah, Hossam M., et al.
Publicado: (2016)

Lansium domesticum—A Fruit with Multi-Benefits: Traditional Uses, Phytochemicals, Nutritional Value, and Bioactivities
por: Abdallah, Hossam M., et al.
Publicado: (2022)

Assessments of Alpha-Amylase Inhibitory Potential of Tagetes Flavonoids through In Vitro, Molecular Docking, and Molecular Dynamics Simulation Studies
por: Mohamed, Gamal A., et al.
Publicado: (2023)

Major flavonoids from Psiadia punctulata produce vasodilation via activation of endothelial dependent NO signaling
por: Abdallah, Hossam M., et al.
Publicado: (2020)

Phenolics from Garcinia mangostana alleviate exaggerated vasoconstriction in metabolic syndrome through direct vasodilatation and nitric oxide generation
por: Abdallah, Hossam M., et al.
Publicado: (2016)

Psiadia punctulata major flavonoids alleviate exaggerated vasoconstriction produced by advanced glycation end products
por: Abdallah, Hossam M., et al.
Publicado: (2019)

Stachybotrys chartarum—A Hidden Treasure: Secondary Metabolites, Bioactivities, and Biotechnological Relevance
por: Ibrahim, Sabrin R. M., et al.
Publicado: (2022)

Hepatoprotective Effect of Silver Nanoparticles at Two Different Particle Sizes: Comparative Study with and without Silymarin
por: Elfaky, Mahmoud A., et al.
Publicado: (2022)

Microbial Natural Products as Potential Inhibitors of SARS-CoV-2 Main Protease (M(pro))
por: Sayed, Ahmed M., et al.
Publicado: (2020)

Molecular docking studies of HIV TAT and sitagliptin nano-formula as potential therapeutic targeting SARS-CoV2 protease
por: Asfour, Hani Z., et al.
Publicado: (2021)

Optimization of Hyaluronate-Based Liposomes to Augment the Oral Delivery and the Bioavailability of Berberine
por: Kutbi, Hussam I., et al.
Publicado: (2021)

Self-Nanoemulsifying Drug Delivery System Loaded with Psiadia punctulata Major Metabolites for Hypertensive Emergencies: Effect on Hemodynamics and Cardiac Conductance
por: Abdallah, Hossam M., et al.
Publicado: (2021)

Advances in Fungal Phenaloenones—Natural Metabolites with Great Promise: Biosynthesis, Bioactivities, and an In Silico Evaluation of Their Potential as Human Glucose Transporter 1 Inhibitors
por: Ibrahim, Sabrin R. M., et al.
Publicado: (2022)

Repurposing of known anti-virals as potential inhibitors for SARS-CoV-2 main protease using molecular docking analysis
por: Hakmi, Mohammed, et al.
Publicado: (2020)

6-Paradol Alleviates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by Inhibiting AKT/mTOR Axis
por: Binmahfouz, Lenah S., et al.
Publicado: (2022)

From Repurposing to Redesign: Optimization of Boceprevir to Highly Potent Inhibitors of the SARS-CoV-2 Main Protease †
por: Göhl, Matthias, et al.
Publicado: (2022)

Anti-Helicobacter, Antitubercular and Cytotoxic Activities of Scalaranes from the Red Sea Sponge Hyrtios erectus †
por: Alahdal, Abdulrahman M., et al.
Publicado: (2018)

Anti-Proliferative, Cytotoxic and Antioxidant Properties of the Methanolic Extracts of Five Saudi Arabian Flora with Folkloric Medicinal Use: Aizoon canariense, Citrullus colocynthis, Maerua crassifolia, Rhazya stricta and Tribulus macropterus
por: Yonbawi, Ahmed R., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_29c19t09u8k3a5cggi6o99pro6