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Prolyl Hydroxylase 3 Knockdown Accelerates VHL-Mutant Kidney Cancer Growth In Vivo

Von Hippel Lindau (VHL) inactivation, which is common in clear cell renal cell carcinoma (ccRCC), leads directly to the disruption of oxygen homoeostasis. VHL works through hypoxia-inducible factors (HIFs). Within this VHL-HIF system, prolyl hydroxylases (PHDs) are the intermediary proteins that ini...

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Detalles Bibliográficos
Autores principales:	Zacharias, Niki M., Wang, Lei, Maity, Tapati, Li, Li, Millward, Steven W., Karam, Jose A., Wood, Christopher G., Navai, Neema
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001211/ https://www.ncbi.nlm.nih.gov/pubmed/33799686 http://dx.doi.org/10.3390/ijms22062849

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