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Stem Cells in Cardiovascular Diseases: 30,000-Foot View
Stem cell and regenerative approaches that might rejuvenate the heart have immense intuitive appeal for the public and scientific communities. Hopes were fueled by initial findings from preclinical models that suggested that easily obtained bone marrow cells might have significant reparative capabil...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001267/ https://www.ncbi.nlm.nih.gov/pubmed/33803227 http://dx.doi.org/10.3390/cells10030600 |
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author | Povsic, Thomas J. Gersh, Bernard J. |
author_facet | Povsic, Thomas J. Gersh, Bernard J. |
author_sort | Povsic, Thomas J. |
collection | PubMed |
description | Stem cell and regenerative approaches that might rejuvenate the heart have immense intuitive appeal for the public and scientific communities. Hopes were fueled by initial findings from preclinical models that suggested that easily obtained bone marrow cells might have significant reparative capabilities; however, after initial encouraging pre-clinical and early clinical findings, the realities of clinical development have placed a damper on the field. Clinical trials were often designed to detect exceptionally large treatment effects with modest patient numbers with subsequent disappointing results. First generation approaches were likely overly simplistic and relied on a relatively primitive understanding of regenerative mechanisms and capabilities. Nonetheless, the field continues to move forward and novel cell derivatives, platforms, and cell/device combinations, coupled with a better understanding of the mechanisms that lead to regenerative capabilities in more primitive models and modifications in clinical trial design suggest a brighter future. |
format | Online Article Text |
id | pubmed-8001267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80012672021-03-28 Stem Cells in Cardiovascular Diseases: 30,000-Foot View Povsic, Thomas J. Gersh, Bernard J. Cells Review Stem cell and regenerative approaches that might rejuvenate the heart have immense intuitive appeal for the public and scientific communities. Hopes were fueled by initial findings from preclinical models that suggested that easily obtained bone marrow cells might have significant reparative capabilities; however, after initial encouraging pre-clinical and early clinical findings, the realities of clinical development have placed a damper on the field. Clinical trials were often designed to detect exceptionally large treatment effects with modest patient numbers with subsequent disappointing results. First generation approaches were likely overly simplistic and relied on a relatively primitive understanding of regenerative mechanisms and capabilities. Nonetheless, the field continues to move forward and novel cell derivatives, platforms, and cell/device combinations, coupled with a better understanding of the mechanisms that lead to regenerative capabilities in more primitive models and modifications in clinical trial design suggest a brighter future. MDPI 2021-03-09 /pmc/articles/PMC8001267/ /pubmed/33803227 http://dx.doi.org/10.3390/cells10030600 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Review Povsic, Thomas J. Gersh, Bernard J. Stem Cells in Cardiovascular Diseases: 30,000-Foot View |
title | Stem Cells in Cardiovascular Diseases: 30,000-Foot View |
title_full | Stem Cells in Cardiovascular Diseases: 30,000-Foot View |
title_fullStr | Stem Cells in Cardiovascular Diseases: 30,000-Foot View |
title_full_unstemmed | Stem Cells in Cardiovascular Diseases: 30,000-Foot View |
title_short | Stem Cells in Cardiovascular Diseases: 30,000-Foot View |
title_sort | stem cells in cardiovascular diseases: 30,000-foot view |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001267/ https://www.ncbi.nlm.nih.gov/pubmed/33803227 http://dx.doi.org/10.3390/cells10030600 |
work_keys_str_mv | AT povsicthomasj stemcellsincardiovasculardiseases30000footview AT gershbernardj stemcellsincardiovasculardiseases30000footview |