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Stem Cells in Cardiovascular Diseases: 30,000-Foot View

Stem cell and regenerative approaches that might rejuvenate the heart have immense intuitive appeal for the public and scientific communities. Hopes were fueled by initial findings from preclinical models that suggested that easily obtained bone marrow cells might have significant reparative capabil...

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Detalles Bibliográficos
Autores principales: Povsic, Thomas J., Gersh, Bernard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001267/
https://www.ncbi.nlm.nih.gov/pubmed/33803227
http://dx.doi.org/10.3390/cells10030600
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author Povsic, Thomas J.
Gersh, Bernard J.
author_facet Povsic, Thomas J.
Gersh, Bernard J.
author_sort Povsic, Thomas J.
collection PubMed
description Stem cell and regenerative approaches that might rejuvenate the heart have immense intuitive appeal for the public and scientific communities. Hopes were fueled by initial findings from preclinical models that suggested that easily obtained bone marrow cells might have significant reparative capabilities; however, after initial encouraging pre-clinical and early clinical findings, the realities of clinical development have placed a damper on the field. Clinical trials were often designed to detect exceptionally large treatment effects with modest patient numbers with subsequent disappointing results. First generation approaches were likely overly simplistic and relied on a relatively primitive understanding of regenerative mechanisms and capabilities. Nonetheless, the field continues to move forward and novel cell derivatives, platforms, and cell/device combinations, coupled with a better understanding of the mechanisms that lead to regenerative capabilities in more primitive models and modifications in clinical trial design suggest a brighter future.
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spelling pubmed-80012672021-03-28 Stem Cells in Cardiovascular Diseases: 30,000-Foot View Povsic, Thomas J. Gersh, Bernard J. Cells Review Stem cell and regenerative approaches that might rejuvenate the heart have immense intuitive appeal for the public and scientific communities. Hopes were fueled by initial findings from preclinical models that suggested that easily obtained bone marrow cells might have significant reparative capabilities; however, after initial encouraging pre-clinical and early clinical findings, the realities of clinical development have placed a damper on the field. Clinical trials were often designed to detect exceptionally large treatment effects with modest patient numbers with subsequent disappointing results. First generation approaches were likely overly simplistic and relied on a relatively primitive understanding of regenerative mechanisms and capabilities. Nonetheless, the field continues to move forward and novel cell derivatives, platforms, and cell/device combinations, coupled with a better understanding of the mechanisms that lead to regenerative capabilities in more primitive models and modifications in clinical trial design suggest a brighter future. MDPI 2021-03-09 /pmc/articles/PMC8001267/ /pubmed/33803227 http://dx.doi.org/10.3390/cells10030600 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Povsic, Thomas J.
Gersh, Bernard J.
Stem Cells in Cardiovascular Diseases: 30,000-Foot View
title Stem Cells in Cardiovascular Diseases: 30,000-Foot View
title_full Stem Cells in Cardiovascular Diseases: 30,000-Foot View
title_fullStr Stem Cells in Cardiovascular Diseases: 30,000-Foot View
title_full_unstemmed Stem Cells in Cardiovascular Diseases: 30,000-Foot View
title_short Stem Cells in Cardiovascular Diseases: 30,000-Foot View
title_sort stem cells in cardiovascular diseases: 30,000-foot view
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001267/
https://www.ncbi.nlm.nih.gov/pubmed/33803227
http://dx.doi.org/10.3390/cells10030600
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