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Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson’s Disease

(1) Background: Monoamine neurotransmitters play essential roles in the normal functioning of our nervous system. However, the metabolism of monoamine neurotransmitters is accompanied by the production of neurotoxic metabolites, and inefficient removal of the metabolites has been suggested to cause...

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Autores principales: Yu, Rwei-Ling, Tu, Shao-Ching, Wu, Ruey-Meei, Lu, Pei-An, Tan, Chun-Hsiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001371/
https://www.ncbi.nlm.nih.gov/pubmed/33808974
http://dx.doi.org/10.3390/brainsci11030361
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author Yu, Rwei-Ling
Tu, Shao-Ching
Wu, Ruey-Meei
Lu, Pei-An
Tan, Chun-Hsiang
author_facet Yu, Rwei-Ling
Tu, Shao-Ching
Wu, Ruey-Meei
Lu, Pei-An
Tan, Chun-Hsiang
author_sort Yu, Rwei-Ling
collection PubMed
description (1) Background: Monoamine neurotransmitters play essential roles in the normal functioning of our nervous system. However, the metabolism of monoamine neurotransmitters is accompanied by the production of neurotoxic metabolites, and inefficient removal of the metabolites has been suggested to cause neurodegeneration. (2) Methods: To examine the effect of reduced activity of catechol-O-methyltransferase (COMT) and aldehyde dehydrogenase 2 (ALDH2) conferred by single nucleotide polymorphisms COMT rs4680(A) and ALDH2 rs671(A) on the symptoms of patients with Parkinson’s disease (PD), a total of 114 PD patients were recruited cross-sectionally and received genotyping for rs4680 and rs671 along with MDS-UPDRS evaluation. (3) Results: We found that patients carrying rs4680(A) had more severe bradykinesia in the upper extremity and rest tremor. Besides, patients carrying rs671(A) had more difficulty maintaining personal hygiene, while patients with genotype rs671(GG) had higher scores in the item “depressed mood.” More importantly, we found the effect of rs4680 to be moderated by rs671 SNP for the symptom of “hand movements.” The detrimental impact of rs4680(A) is more pronounced in the presence of genotype rs671(GG). (4) Conclusions: This study facilitates a deeper understanding of the detrimental effect of reduced activity of COMT and ALDH2 conferred by genetic variation and provides novel insight into the interactions between enzymes metabolizing monoamine neurotransmitters in the pathogenesis of PD.
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spelling pubmed-80013712021-03-28 Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson’s Disease Yu, Rwei-Ling Tu, Shao-Ching Wu, Ruey-Meei Lu, Pei-An Tan, Chun-Hsiang Brain Sci Article (1) Background: Monoamine neurotransmitters play essential roles in the normal functioning of our nervous system. However, the metabolism of monoamine neurotransmitters is accompanied by the production of neurotoxic metabolites, and inefficient removal of the metabolites has been suggested to cause neurodegeneration. (2) Methods: To examine the effect of reduced activity of catechol-O-methyltransferase (COMT) and aldehyde dehydrogenase 2 (ALDH2) conferred by single nucleotide polymorphisms COMT rs4680(A) and ALDH2 rs671(A) on the symptoms of patients with Parkinson’s disease (PD), a total of 114 PD patients were recruited cross-sectionally and received genotyping for rs4680 and rs671 along with MDS-UPDRS evaluation. (3) Results: We found that patients carrying rs4680(A) had more severe bradykinesia in the upper extremity and rest tremor. Besides, patients carrying rs671(A) had more difficulty maintaining personal hygiene, while patients with genotype rs671(GG) had higher scores in the item “depressed mood.” More importantly, we found the effect of rs4680 to be moderated by rs671 SNP for the symptom of “hand movements.” The detrimental impact of rs4680(A) is more pronounced in the presence of genotype rs671(GG). (4) Conclusions: This study facilitates a deeper understanding of the detrimental effect of reduced activity of COMT and ALDH2 conferred by genetic variation and provides novel insight into the interactions between enzymes metabolizing monoamine neurotransmitters in the pathogenesis of PD. MDPI 2021-03-12 /pmc/articles/PMC8001371/ /pubmed/33808974 http://dx.doi.org/10.3390/brainsci11030361 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Yu, Rwei-Ling
Tu, Shao-Ching
Wu, Ruey-Meei
Lu, Pei-An
Tan, Chun-Hsiang
Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson’s Disease
title Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson’s Disease
title_full Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson’s Disease
title_fullStr Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson’s Disease
title_full_unstemmed Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson’s Disease
title_short Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson’s Disease
title_sort interactions of comt and aldh2 genetic polymorphisms on symptoms of parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001371/
https://www.ncbi.nlm.nih.gov/pubmed/33808974
http://dx.doi.org/10.3390/brainsci11030361
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