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Recent Advancements in Nanoparticle-Based Optical Biosensors for Circulating Cancer Biomarkers
The effectiveness of cancer treatment strongly depends on the early detection of the disease. Currently, the most common diagnostic method, tissue biopsy, takes time and can be damaging to the patient. Circulating cancer biomarkers such as circulating tumor DNA, micro-RNA (miRNA), tumor proteins, ex...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001438/ https://www.ncbi.nlm.nih.gov/pubmed/33802028 http://dx.doi.org/10.3390/ma14061339 |
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author | Amri, Chaima Shukla, Arvind Kumar Lee, Jin-Ho |
author_facet | Amri, Chaima Shukla, Arvind Kumar Lee, Jin-Ho |
author_sort | Amri, Chaima |
collection | PubMed |
description | The effectiveness of cancer treatment strongly depends on the early detection of the disease. Currently, the most common diagnostic method, tissue biopsy, takes time and can be damaging to the patient. Circulating cancer biomarkers such as circulating tumor DNA, micro-RNA (miRNA), tumor proteins, exosomes, and circulating tumor cells have repeatedly demonstrated their viability as targets for minimally invasive cancer detection through liquid biopsies. However, among other things, achieving a great sensitivity of detection is still challenging due to the very low concentration of biomarkers in fluid samples. This review will discuss how the recent advances in nanoparticle-based biosensors are overcoming these practical difficulties. This report will be focusing mainly on optical transduction mechanisms of metal nanoparticles (M-NPs), quantum dots (QDs), and upconversion nanoparticles (UCNPs). |
format | Online Article Text |
id | pubmed-8001438 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80014382021-03-28 Recent Advancements in Nanoparticle-Based Optical Biosensors for Circulating Cancer Biomarkers Amri, Chaima Shukla, Arvind Kumar Lee, Jin-Ho Materials (Basel) Review The effectiveness of cancer treatment strongly depends on the early detection of the disease. Currently, the most common diagnostic method, tissue biopsy, takes time and can be damaging to the patient. Circulating cancer biomarkers such as circulating tumor DNA, micro-RNA (miRNA), tumor proteins, exosomes, and circulating tumor cells have repeatedly demonstrated their viability as targets for minimally invasive cancer detection through liquid biopsies. However, among other things, achieving a great sensitivity of detection is still challenging due to the very low concentration of biomarkers in fluid samples. This review will discuss how the recent advances in nanoparticle-based biosensors are overcoming these practical difficulties. This report will be focusing mainly on optical transduction mechanisms of metal nanoparticles (M-NPs), quantum dots (QDs), and upconversion nanoparticles (UCNPs). MDPI 2021-03-10 /pmc/articles/PMC8001438/ /pubmed/33802028 http://dx.doi.org/10.3390/ma14061339 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Amri, Chaima Shukla, Arvind Kumar Lee, Jin-Ho Recent Advancements in Nanoparticle-Based Optical Biosensors for Circulating Cancer Biomarkers |
title | Recent Advancements in Nanoparticle-Based Optical Biosensors for Circulating Cancer Biomarkers |
title_full | Recent Advancements in Nanoparticle-Based Optical Biosensors for Circulating Cancer Biomarkers |
title_fullStr | Recent Advancements in Nanoparticle-Based Optical Biosensors for Circulating Cancer Biomarkers |
title_full_unstemmed | Recent Advancements in Nanoparticle-Based Optical Biosensors for Circulating Cancer Biomarkers |
title_short | Recent Advancements in Nanoparticle-Based Optical Biosensors for Circulating Cancer Biomarkers |
title_sort | recent advancements in nanoparticle-based optical biosensors for circulating cancer biomarkers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001438/ https://www.ncbi.nlm.nih.gov/pubmed/33802028 http://dx.doi.org/10.3390/ma14061339 |
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