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Novel Selective IDO1 Inhibitors with Isoxazolo[5,4-d]pyrimidin-4(5H)-one Scaffold

Indoleamine 2,3-dioxygenase 1 (IDO1) is a promising target in immunomodulation of several pathological conditions, especially cancers. Here we present the synthesis of a series of IDO1 inhibitors with the novel isoxazolo[5,4-d]pyrimidin-4(5H)-one scaffold. A focused library was prepared using a 6- o...

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Detalles Bibliográficos
Autores principales:	Dolšak, Ana, Bratkovič, Tomaž, Mlinarič, Larisa, Ogorevc, Eva, Švajger, Urban, Gobec, Stanislav, Sova, Matej
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001472/ https://www.ncbi.nlm.nih.gov/pubmed/33804161 http://dx.doi.org/10.3390/ph14030265

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