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Cardiovascular and Respiratory Toxicity of Protamine Sulfate in Zebrafish and Rodent Models

Protamine sulfate (PS) is the only available option to reverse the anticoagulant activity of unfractionated heparin (UFH), however it can cause cardiovascular and respiratory complications. We explored the toxicity of PS and its complexes with UFH in zebrafish, rats, and mice. The involvement of nit...

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Detalles Bibliográficos
Autores principales:	Miklosz, Joanna, Kalaska, Bartlomiej, Podlasz, Piotr, Chmielewska-Krzesińska, Małgorzata, Zajączkowski, Miłosz, Kosiński, Adam, Pawlak, Dariusz, Mogielnicki, Andrzej
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001545/ https://www.ncbi.nlm.nih.gov/pubmed/33803176 http://dx.doi.org/10.3390/pharmaceutics13030359

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