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Implications of Tributyrin on Gut Microbiota Shifts Related to Performances of Weaning Piglets
Alternatives to antibiotic treatments are required owing to the ban on the use of these drugs as growth promoters in food animal production. Tributyrin appears to play a role in improving growth performance in pigs, albeit with varying degrees of effectiveness. So far, very little is known about its...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001585/ https://www.ncbi.nlm.nih.gov/pubmed/33809105 http://dx.doi.org/10.3390/microorganisms9030584 |
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author | Miragoli, Francesco Patrone, Vania Prandini, Aldo Sigolo, Samantha Dell’Anno, Matteo Rossi, Luciana Senizza, Alice Morelli, Lorenzo Callegari, Maria Luisa |
author_facet | Miragoli, Francesco Patrone, Vania Prandini, Aldo Sigolo, Samantha Dell’Anno, Matteo Rossi, Luciana Senizza, Alice Morelli, Lorenzo Callegari, Maria Luisa |
author_sort | Miragoli, Francesco |
collection | PubMed |
description | Alternatives to antibiotic treatments are required owing to the ban on the use of these drugs as growth promoters in food animal production. Tributyrin appears to play a role in improving growth performance in pigs, albeit with varying degrees of effectiveness. So far, very little is known about its effects on gut microbiota composition. In this study, we investigated the gut microbiota changes of piglets receiving, at weaning, 0.2% tributyrin added to their basal diet. Microbiota composition was assessed through 16S-rRNA gene sequencing on stools collected from tributyrin and control groups. The functional profiles of microbial communities were predicted from amplicon abundance data. A comparison between dietary groups revealed that tributyrin strongly modulated gut microbiota composition in piglets, increasing the relative abundance of a number of bacterial genera such as Oscillospira, Oscillibacter, Mucispirillum and Butyrivibrio. These genera were positively correlated to animal average daily gain (ADG) and/or body weight (BW). Based on the function profile prediction, the gut microbiome of the tributyrin group possessed an enhanced potential for energy metabolism and a reduced potential for carbohydrate metabolism. In conclusion, our results indicated that tributyrin can promote changes to gut microbial communities, which could contribute to improving animal performance after weaning. |
format | Online Article Text |
id | pubmed-8001585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80015852021-03-28 Implications of Tributyrin on Gut Microbiota Shifts Related to Performances of Weaning Piglets Miragoli, Francesco Patrone, Vania Prandini, Aldo Sigolo, Samantha Dell’Anno, Matteo Rossi, Luciana Senizza, Alice Morelli, Lorenzo Callegari, Maria Luisa Microorganisms Article Alternatives to antibiotic treatments are required owing to the ban on the use of these drugs as growth promoters in food animal production. Tributyrin appears to play a role in improving growth performance in pigs, albeit with varying degrees of effectiveness. So far, very little is known about its effects on gut microbiota composition. In this study, we investigated the gut microbiota changes of piglets receiving, at weaning, 0.2% tributyrin added to their basal diet. Microbiota composition was assessed through 16S-rRNA gene sequencing on stools collected from tributyrin and control groups. The functional profiles of microbial communities were predicted from amplicon abundance data. A comparison between dietary groups revealed that tributyrin strongly modulated gut microbiota composition in piglets, increasing the relative abundance of a number of bacterial genera such as Oscillospira, Oscillibacter, Mucispirillum and Butyrivibrio. These genera were positively correlated to animal average daily gain (ADG) and/or body weight (BW). Based on the function profile prediction, the gut microbiome of the tributyrin group possessed an enhanced potential for energy metabolism and a reduced potential for carbohydrate metabolism. In conclusion, our results indicated that tributyrin can promote changes to gut microbial communities, which could contribute to improving animal performance after weaning. MDPI 2021-03-12 /pmc/articles/PMC8001585/ /pubmed/33809105 http://dx.doi.org/10.3390/microorganisms9030584 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Miragoli, Francesco Patrone, Vania Prandini, Aldo Sigolo, Samantha Dell’Anno, Matteo Rossi, Luciana Senizza, Alice Morelli, Lorenzo Callegari, Maria Luisa Implications of Tributyrin on Gut Microbiota Shifts Related to Performances of Weaning Piglets |
title | Implications of Tributyrin on Gut Microbiota Shifts Related to Performances of Weaning Piglets |
title_full | Implications of Tributyrin on Gut Microbiota Shifts Related to Performances of Weaning Piglets |
title_fullStr | Implications of Tributyrin on Gut Microbiota Shifts Related to Performances of Weaning Piglets |
title_full_unstemmed | Implications of Tributyrin on Gut Microbiota Shifts Related to Performances of Weaning Piglets |
title_short | Implications of Tributyrin on Gut Microbiota Shifts Related to Performances of Weaning Piglets |
title_sort | implications of tributyrin on gut microbiota shifts related to performances of weaning piglets |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001585/ https://www.ncbi.nlm.nih.gov/pubmed/33809105 http://dx.doi.org/10.3390/microorganisms9030584 |
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