Cargando…
Congenital Hypothyroidism: A 2020–2021 Consensus Guidelines Update—An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology
Background: An ENDO-European Reference Network (ERN) initiative was launched that was endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology with 22 participants from the ENDO-ERN and the two societies. The aim was to update the practice guidelines fo...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mary Ann Liebert, Inc., publishers
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001676/ https://www.ncbi.nlm.nih.gov/pubmed/33272083 http://dx.doi.org/10.1089/thy.2020.0333 |
_version_ | 1783671286115860480 |
---|---|
author | van Trotsenburg, Paul Stoupa, Athanasia Léger, Juliane Rohrer, Tilman Peters, Catherine Fugazzola, Laura Cassio, Alessandra Heinrichs, Claudine Beauloye, Veronique Pohlenz, Joachim Rodien, Patrice Coutant, Regis Szinnai, Gabor Murray, Philip Bartés, Beate Luton, Dominique Salerno, Mariacarolina de Sanctis, Luisa Vigone, Mariacristina Krude, Heiko Persani, Luca Polak, Michel |
author_facet | van Trotsenburg, Paul Stoupa, Athanasia Léger, Juliane Rohrer, Tilman Peters, Catherine Fugazzola, Laura Cassio, Alessandra Heinrichs, Claudine Beauloye, Veronique Pohlenz, Joachim Rodien, Patrice Coutant, Regis Szinnai, Gabor Murray, Philip Bartés, Beate Luton, Dominique Salerno, Mariacarolina de Sanctis, Luisa Vigone, Mariacristina Krude, Heiko Persani, Luca Polak, Michel |
author_sort | van Trotsenburg, Paul |
collection | PubMed |
description | Background: An ENDO-European Reference Network (ERN) initiative was launched that was endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology with 22 participants from the ENDO-ERN and the two societies. The aim was to update the practice guidelines for the diagnosis and management of congenital hypothyroidism (CH). A systematic literature search was conducted to identify key articles on neonatal screening, diagnosis, and management of primary and central CH. The evidence-based guidelines were graded with the Grading of Recommendations, Assessment, Development and Evaluation system, describing both the strength of recommendations and the quality of evidence. In the absence of sufficient evidence, conclusions were based on expert opinion. Summary: The recommendations include the various neonatal screening approaches for CH as well as the etiology (also genetics), diagnostics, treatment, and prognosis of both primary and central CH. When CH is diagnosed, the expert panel recommends the immediate start of correctly dosed levothyroxine treatment and frequent follow-up including laboratory testing to keep thyroid hormone levels in their target ranges, timely assessment of the need to continue treatment, attention for neurodevelopment and neurosensory functions, and, if necessary, consulting other health professionals, and education of the child and family about CH. Harmonization of diagnostics, treatment, and follow-up will optimize patient outcomes. Lastly, all individuals with CH are entitled to a well-planned transition of care from pediatrics to adult medicine. Conclusions: This consensus guidelines update should be used to further optimize detection, diagnosis, treatment, and follow-up of children with all forms of CH in the light of the most recent evidence. It should be helpful in convincing health authorities of the benefits of neonatal screening for CH. Further epidemiological and experimental studies are needed to understand the increased incidence of this condition. |
format | Online Article Text |
id | pubmed-8001676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Mary Ann Liebert, Inc., publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-80016762021-03-30 Congenital Hypothyroidism: A 2020–2021 Consensus Guidelines Update—An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology van Trotsenburg, Paul Stoupa, Athanasia Léger, Juliane Rohrer, Tilman Peters, Catherine Fugazzola, Laura Cassio, Alessandra Heinrichs, Claudine Beauloye, Veronique Pohlenz, Joachim Rodien, Patrice Coutant, Regis Szinnai, Gabor Murray, Philip Bartés, Beate Luton, Dominique Salerno, Mariacarolina de Sanctis, Luisa Vigone, Mariacristina Krude, Heiko Persani, Luca Polak, Michel Thyroid Special Articles Background: An ENDO-European Reference Network (ERN) initiative was launched that was endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology with 22 participants from the ENDO-ERN and the two societies. The aim was to update the practice guidelines for the diagnosis and management of congenital hypothyroidism (CH). A systematic literature search was conducted to identify key articles on neonatal screening, diagnosis, and management of primary and central CH. The evidence-based guidelines were graded with the Grading of Recommendations, Assessment, Development and Evaluation system, describing both the strength of recommendations and the quality of evidence. In the absence of sufficient evidence, conclusions were based on expert opinion. Summary: The recommendations include the various neonatal screening approaches for CH as well as the etiology (also genetics), diagnostics, treatment, and prognosis of both primary and central CH. When CH is diagnosed, the expert panel recommends the immediate start of correctly dosed levothyroxine treatment and frequent follow-up including laboratory testing to keep thyroid hormone levels in their target ranges, timely assessment of the need to continue treatment, attention for neurodevelopment and neurosensory functions, and, if necessary, consulting other health professionals, and education of the child and family about CH. Harmonization of diagnostics, treatment, and follow-up will optimize patient outcomes. Lastly, all individuals with CH are entitled to a well-planned transition of care from pediatrics to adult medicine. Conclusions: This consensus guidelines update should be used to further optimize detection, diagnosis, treatment, and follow-up of children with all forms of CH in the light of the most recent evidence. It should be helpful in convincing health authorities of the benefits of neonatal screening for CH. Further epidemiological and experimental studies are needed to understand the increased incidence of this condition. Mary Ann Liebert, Inc., publishers 2021-03-01 2021-03-12 /pmc/articles/PMC8001676/ /pubmed/33272083 http://dx.doi.org/10.1089/thy.2020.0333 Text en © Paul van Trotsenburg et al., 2021; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License [CC-BY-NC] (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited. |
spellingShingle | Special Articles van Trotsenburg, Paul Stoupa, Athanasia Léger, Juliane Rohrer, Tilman Peters, Catherine Fugazzola, Laura Cassio, Alessandra Heinrichs, Claudine Beauloye, Veronique Pohlenz, Joachim Rodien, Patrice Coutant, Regis Szinnai, Gabor Murray, Philip Bartés, Beate Luton, Dominique Salerno, Mariacarolina de Sanctis, Luisa Vigone, Mariacristina Krude, Heiko Persani, Luca Polak, Michel Congenital Hypothyroidism: A 2020–2021 Consensus Guidelines Update—An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology |
title | Congenital Hypothyroidism: A 2020–2021 Consensus Guidelines Update—An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology |
title_full | Congenital Hypothyroidism: A 2020–2021 Consensus Guidelines Update—An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology |
title_fullStr | Congenital Hypothyroidism: A 2020–2021 Consensus Guidelines Update—An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology |
title_full_unstemmed | Congenital Hypothyroidism: A 2020–2021 Consensus Guidelines Update—An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology |
title_short | Congenital Hypothyroidism: A 2020–2021 Consensus Guidelines Update—An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology |
title_sort | congenital hypothyroidism: a 2020–2021 consensus guidelines update—an endo-european reference network initiative endorsed by the european society for pediatric endocrinology and the european society for endocrinology |
topic | Special Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001676/ https://www.ncbi.nlm.nih.gov/pubmed/33272083 http://dx.doi.org/10.1089/thy.2020.0333 |
work_keys_str_mv | AT vantrotsenburgpaul congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology AT stoupaathanasia congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology AT legerjuliane congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology AT rohrertilman congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology AT peterscatherine congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology AT fugazzolalaura congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology AT cassioalessandra congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology AT heinrichsclaudine congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology AT beauloyeveronique congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology AT pohlenzjoachim congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology AT rodienpatrice congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology AT coutantregis congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology AT szinnaigabor congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology AT murrayphilip congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology AT bartesbeate congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology AT lutondominique congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology AT salernomariacarolina congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology AT desanctisluisa congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology AT vigonemariacristina congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology AT krudeheiko congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology AT persaniluca congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology AT polakmichel congenitalhypothyroidisma20202021consensusguidelinesupdateanendoeuropeanreferencenetworkinitiativeendorsedbytheeuropeansocietyforpediatricendocrinologyandtheeuropeansocietyforendocrinology |