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MDM2 Amplified Sarcomas: A Literature Review

Murine Double Minute Clone 2, located at 12q15, is an oncogene that codes for an oncoprotein of which the association with p53 was discovered 30 years ago. The most important function of MDM2 is to control p53 activity; it is in fact the best documented negative regulator of p53. Mutations of the tu...

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Autor principal: Sciot, Raf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001728/
https://www.ncbi.nlm.nih.gov/pubmed/33799733
http://dx.doi.org/10.3390/diagnostics11030496
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author Sciot, Raf
author_facet Sciot, Raf
author_sort Sciot, Raf
collection PubMed
description Murine Double Minute Clone 2, located at 12q15, is an oncogene that codes for an oncoprotein of which the association with p53 was discovered 30 years ago. The most important function of MDM2 is to control p53 activity; it is in fact the best documented negative regulator of p53. Mutations of the tumor suppressor gene p53 represent the most frequent genetic change in human cancers. By overexpressing MDM2, cancer cells have another means to block p53. The sarcomas in which MDM2 amplification is a hallmark are well-differentiated liposarcoma/atypical lipomatous tumor, dedifferentiated liposarcoma, intimal sarcoma, and low-grade osteosarcoma. The purpose of this review is to summarize the typical clinical, histopathological, immunohistochemical, and genetic features of these tumors.
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spelling pubmed-80017282021-03-28 MDM2 Amplified Sarcomas: A Literature Review Sciot, Raf Diagnostics (Basel) Review Murine Double Minute Clone 2, located at 12q15, is an oncogene that codes for an oncoprotein of which the association with p53 was discovered 30 years ago. The most important function of MDM2 is to control p53 activity; it is in fact the best documented negative regulator of p53. Mutations of the tumor suppressor gene p53 represent the most frequent genetic change in human cancers. By overexpressing MDM2, cancer cells have another means to block p53. The sarcomas in which MDM2 amplification is a hallmark are well-differentiated liposarcoma/atypical lipomatous tumor, dedifferentiated liposarcoma, intimal sarcoma, and low-grade osteosarcoma. The purpose of this review is to summarize the typical clinical, histopathological, immunohistochemical, and genetic features of these tumors. MDPI 2021-03-11 /pmc/articles/PMC8001728/ /pubmed/33799733 http://dx.doi.org/10.3390/diagnostics11030496 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Sciot, Raf
MDM2 Amplified Sarcomas: A Literature Review
title MDM2 Amplified Sarcomas: A Literature Review
title_full MDM2 Amplified Sarcomas: A Literature Review
title_fullStr MDM2 Amplified Sarcomas: A Literature Review
title_full_unstemmed MDM2 Amplified Sarcomas: A Literature Review
title_short MDM2 Amplified Sarcomas: A Literature Review
title_sort mdm2 amplified sarcomas: a literature review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001728/
https://www.ncbi.nlm.nih.gov/pubmed/33799733
http://dx.doi.org/10.3390/diagnostics11030496
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