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Changes in Salivary Amylase and Glucose in Diabetes: A Scoping Review

Background and Objective: Diabetes mellitus (DM) is a common long-term disease which can be related with salivary amylase levels. DM has recently been associated with salivary amylase diagnostics that could further impair diagnoses in the diabetic population, as well as being an interesting alternat...

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Autores principales: Pérez-Ros, Pilar, Navarro-Flores, Emmanuel, Julián-Rochina, Ivan, Martínez-Arnau, Francisco Miguel, Cauli, Omar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001770/
https://www.ncbi.nlm.nih.gov/pubmed/33800850
http://dx.doi.org/10.3390/diagnostics11030453
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author Pérez-Ros, Pilar
Navarro-Flores, Emmanuel
Julián-Rochina, Ivan
Martínez-Arnau, Francisco Miguel
Cauli, Omar
author_facet Pérez-Ros, Pilar
Navarro-Flores, Emmanuel
Julián-Rochina, Ivan
Martínez-Arnau, Francisco Miguel
Cauli, Omar
author_sort Pérez-Ros, Pilar
collection PubMed
description Background and Objective: Diabetes mellitus (DM) is a common long-term disease which can be related with salivary amylase levels. DM has recently been associated with salivary amylase diagnostics that could further impair diagnoses in the diabetic population, as well as being an interesting alternative to traditional methods of determine glucose levels. The main advantage of this method is related to the fact that it is a fast diagnostic method. The DM population experiences changes to their metabolism which affects their salivary parameters, making this an alternative procedure for diagnosis and follow-up of the illness due to the non-invasive nature of salivary analyzes. The objective of this review is to summarize the evidence regarding the changes in salivary amylase and glucose levels, and their relationship with blood markers of glycemic control used in clinical settings such as blood glucose and glycated hemoglobin. The differences in salivary amylase levels depending on the method of saliva collection under fasting or non-fasting conditions. The changes in salivary amylase depends on the type of diabetes, the type of insulin treatment or the quality of glycemic control. Conclusions: Salivary amylase concentration is increased in diabetic patients in most of the studies and salivary glucose concentration in all studies in both fasting and non-fasting (post-prandial) conditions. Salivary amylase and glucose concentration represent potential non-invasive biomarkers to evaluate glycemic control and clinical management of diabetic patients, although it is necessary to evaluate the influence of potential modulating factors such as age, duration diseases, sex and the effects of pharmacological treatments in these outcomes which remained to be elucidated.
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spelling pubmed-80017702021-03-28 Changes in Salivary Amylase and Glucose in Diabetes: A Scoping Review Pérez-Ros, Pilar Navarro-Flores, Emmanuel Julián-Rochina, Ivan Martínez-Arnau, Francisco Miguel Cauli, Omar Diagnostics (Basel) Review Background and Objective: Diabetes mellitus (DM) is a common long-term disease which can be related with salivary amylase levels. DM has recently been associated with salivary amylase diagnostics that could further impair diagnoses in the diabetic population, as well as being an interesting alternative to traditional methods of determine glucose levels. The main advantage of this method is related to the fact that it is a fast diagnostic method. The DM population experiences changes to their metabolism which affects their salivary parameters, making this an alternative procedure for diagnosis and follow-up of the illness due to the non-invasive nature of salivary analyzes. The objective of this review is to summarize the evidence regarding the changes in salivary amylase and glucose levels, and their relationship with blood markers of glycemic control used in clinical settings such as blood glucose and glycated hemoglobin. The differences in salivary amylase levels depending on the method of saliva collection under fasting or non-fasting conditions. The changes in salivary amylase depends on the type of diabetes, the type of insulin treatment or the quality of glycemic control. Conclusions: Salivary amylase concentration is increased in diabetic patients in most of the studies and salivary glucose concentration in all studies in both fasting and non-fasting (post-prandial) conditions. Salivary amylase and glucose concentration represent potential non-invasive biomarkers to evaluate glycemic control and clinical management of diabetic patients, although it is necessary to evaluate the influence of potential modulating factors such as age, duration diseases, sex and the effects of pharmacological treatments in these outcomes which remained to be elucidated. MDPI 2021-03-06 /pmc/articles/PMC8001770/ /pubmed/33800850 http://dx.doi.org/10.3390/diagnostics11030453 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Pérez-Ros, Pilar
Navarro-Flores, Emmanuel
Julián-Rochina, Ivan
Martínez-Arnau, Francisco Miguel
Cauli, Omar
Changes in Salivary Amylase and Glucose in Diabetes: A Scoping Review
title Changes in Salivary Amylase and Glucose in Diabetes: A Scoping Review
title_full Changes in Salivary Amylase and Glucose in Diabetes: A Scoping Review
title_fullStr Changes in Salivary Amylase and Glucose in Diabetes: A Scoping Review
title_full_unstemmed Changes in Salivary Amylase and Glucose in Diabetes: A Scoping Review
title_short Changes in Salivary Amylase and Glucose in Diabetes: A Scoping Review
title_sort changes in salivary amylase and glucose in diabetes: a scoping review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001770/
https://www.ncbi.nlm.nih.gov/pubmed/33800850
http://dx.doi.org/10.3390/diagnostics11030453
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