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MicroRNAs, Parkinson’s Disease, and Diabetes Mellitus
Parkinson’s disease (PD) is a neurodegenerative disorder that affects 1% of the population over the age of 60. Diabetes Mellitus (DM) is a metabolic disorder that affects approximately 25% of adults over the age of 60. Recent studies showed that DM increases the risk of developing PD. The link betwe...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001823/ https://www.ncbi.nlm.nih.gov/pubmed/33799467 http://dx.doi.org/10.3390/ijms22062953 |
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author | Wang, Hsiuying |
author_facet | Wang, Hsiuying |
author_sort | Wang, Hsiuying |
collection | PubMed |
description | Parkinson’s disease (PD) is a neurodegenerative disorder that affects 1% of the population over the age of 60. Diabetes Mellitus (DM) is a metabolic disorder that affects approximately 25% of adults over the age of 60. Recent studies showed that DM increases the risk of developing PD. The link between DM and PD has been discussed in the literature in relation to different mechanisms including mitochondrial dysfunction, oxidative stress, and protein aggregation. In this paper, we review the common microRNA (miRNA) biomarkers of both diseases. miRNAs play an important role in cell differentiation, development, the regulation of the cell cycle, and apoptosis. They are also involved in the pathology of many diseases. miRNAs can mediate the insulin pathway and glucose absorption. miRNAs can also regulate PD-related genes. Therefore, exploring the common miRNA biomarkers of both PD and DM can shed a light on how these two diseases are correlated, and targeting miRNAs is a potential therapeutic opportunity for both diseases. |
format | Online Article Text |
id | pubmed-8001823 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80018232021-03-28 MicroRNAs, Parkinson’s Disease, and Diabetes Mellitus Wang, Hsiuying Int J Mol Sci Review Parkinson’s disease (PD) is a neurodegenerative disorder that affects 1% of the population over the age of 60. Diabetes Mellitus (DM) is a metabolic disorder that affects approximately 25% of adults over the age of 60. Recent studies showed that DM increases the risk of developing PD. The link between DM and PD has been discussed in the literature in relation to different mechanisms including mitochondrial dysfunction, oxidative stress, and protein aggregation. In this paper, we review the common microRNA (miRNA) biomarkers of both diseases. miRNAs play an important role in cell differentiation, development, the regulation of the cell cycle, and apoptosis. They are also involved in the pathology of many diseases. miRNAs can mediate the insulin pathway and glucose absorption. miRNAs can also regulate PD-related genes. Therefore, exploring the common miRNA biomarkers of both PD and DM can shed a light on how these two diseases are correlated, and targeting miRNAs is a potential therapeutic opportunity for both diseases. MDPI 2021-03-14 /pmc/articles/PMC8001823/ /pubmed/33799467 http://dx.doi.org/10.3390/ijms22062953 Text en © 2021 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wang, Hsiuying MicroRNAs, Parkinson’s Disease, and Diabetes Mellitus |
title | MicroRNAs, Parkinson’s Disease, and Diabetes Mellitus |
title_full | MicroRNAs, Parkinson’s Disease, and Diabetes Mellitus |
title_fullStr | MicroRNAs, Parkinson’s Disease, and Diabetes Mellitus |
title_full_unstemmed | MicroRNAs, Parkinson’s Disease, and Diabetes Mellitus |
title_short | MicroRNAs, Parkinson’s Disease, and Diabetes Mellitus |
title_sort | micrornas, parkinson’s disease, and diabetes mellitus |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001823/ https://www.ncbi.nlm.nih.gov/pubmed/33799467 http://dx.doi.org/10.3390/ijms22062953 |
work_keys_str_mv | AT wanghsiuying micrornasparkinsonsdiseaseanddiabetesmellitus |