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Multiple Reassortants of H5N8 Clade 2.3.4.4b Highly Pathogenic Avian Influenza Viruses Detected in South Korea during the Winter of 2020–2021

During October 2020–January 2021, we isolated a total of 67 highly pathogenic avian influenza (HPAI) H5N8 viruses from wild birds and outbreaks in poultry in South Korea. We sequenced the isolates and performed phylogenetic analysis of complete genome sequences to determine the origin, evolution, an...

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Autores principales: Baek, Yoon-Gi, Lee, Yu-Na, Lee, Dong-Hun, Shin, Jae-in, Lee, Ji-Ho, Chung, David H., Lee, Eun-Kyoung, Heo, Gyeong-Beom, Sagong, Mingeun, Kye, Soo-Jeong, Lee, Kwang-Nyeong, Lee, Myoung-Heon, Lee, Youn-Jeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001867/
https://www.ncbi.nlm.nih.gov/pubmed/33809549
http://dx.doi.org/10.3390/v13030490
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author Baek, Yoon-Gi
Lee, Yu-Na
Lee, Dong-Hun
Shin, Jae-in
Lee, Ji-Ho
Chung, David H.
Lee, Eun-Kyoung
Heo, Gyeong-Beom
Sagong, Mingeun
Kye, Soo-Jeong
Lee, Kwang-Nyeong
Lee, Myoung-Heon
Lee, Youn-Jeong
author_facet Baek, Yoon-Gi
Lee, Yu-Na
Lee, Dong-Hun
Shin, Jae-in
Lee, Ji-Ho
Chung, David H.
Lee, Eun-Kyoung
Heo, Gyeong-Beom
Sagong, Mingeun
Kye, Soo-Jeong
Lee, Kwang-Nyeong
Lee, Myoung-Heon
Lee, Youn-Jeong
author_sort Baek, Yoon-Gi
collection PubMed
description During October 2020–January 2021, we isolated a total of 67 highly pathogenic avian influenza (HPAI) H5N8 viruses from wild birds and outbreaks in poultry in South Korea. We sequenced the isolates and performed phylogenetic analysis of complete genome sequences to determine the origin, evolution, and spread patterns of these viruses. Phylogenetic analysis of the hemagglutinin (HA) gene showed that all the isolates belong to H5 clade 2.3.4.4 subgroup B (2.3.4.4b) and form two distinct genetic clusters, G1 and G2. The cluster G1 was closely related to the 2.3.4.4b H5N8 HPAI viruses detected in Europe in early 2020, while the cluster G2 had a close genetic relationship with the 2.3.4.4b H5N8 viruses that circulated in Europe in late 2020. A total of seven distinct genotypes were identified, including five novel reassortants carrying internal genes of low pathogenic avian influenza viruses. Our Bayesian discrete trait phylodynamic analysis between host types suggests that the viruses initially disseminated from migratory waterfowl to domestic duck farms in South Korea. Subsequently, domestic duck farms most likely contributed to the transmission of HPAI viruses to chicken and minor poultry farms, highlighting the need for enhanced, high levels of biosecurity measures at domestic duck farms to effectively prevent the introduction and spread of HPAI.
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spelling pubmed-80018672021-03-28 Multiple Reassortants of H5N8 Clade 2.3.4.4b Highly Pathogenic Avian Influenza Viruses Detected in South Korea during the Winter of 2020–2021 Baek, Yoon-Gi Lee, Yu-Na Lee, Dong-Hun Shin, Jae-in Lee, Ji-Ho Chung, David H. Lee, Eun-Kyoung Heo, Gyeong-Beom Sagong, Mingeun Kye, Soo-Jeong Lee, Kwang-Nyeong Lee, Myoung-Heon Lee, Youn-Jeong Viruses Communication During October 2020–January 2021, we isolated a total of 67 highly pathogenic avian influenza (HPAI) H5N8 viruses from wild birds and outbreaks in poultry in South Korea. We sequenced the isolates and performed phylogenetic analysis of complete genome sequences to determine the origin, evolution, and spread patterns of these viruses. Phylogenetic analysis of the hemagglutinin (HA) gene showed that all the isolates belong to H5 clade 2.3.4.4 subgroup B (2.3.4.4b) and form two distinct genetic clusters, G1 and G2. The cluster G1 was closely related to the 2.3.4.4b H5N8 HPAI viruses detected in Europe in early 2020, while the cluster G2 had a close genetic relationship with the 2.3.4.4b H5N8 viruses that circulated in Europe in late 2020. A total of seven distinct genotypes were identified, including five novel reassortants carrying internal genes of low pathogenic avian influenza viruses. Our Bayesian discrete trait phylodynamic analysis between host types suggests that the viruses initially disseminated from migratory waterfowl to domestic duck farms in South Korea. Subsequently, domestic duck farms most likely contributed to the transmission of HPAI viruses to chicken and minor poultry farms, highlighting the need for enhanced, high levels of biosecurity measures at domestic duck farms to effectively prevent the introduction and spread of HPAI. MDPI 2021-03-16 /pmc/articles/PMC8001867/ /pubmed/33809549 http://dx.doi.org/10.3390/v13030490 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Communication
Baek, Yoon-Gi
Lee, Yu-Na
Lee, Dong-Hun
Shin, Jae-in
Lee, Ji-Ho
Chung, David H.
Lee, Eun-Kyoung
Heo, Gyeong-Beom
Sagong, Mingeun
Kye, Soo-Jeong
Lee, Kwang-Nyeong
Lee, Myoung-Heon
Lee, Youn-Jeong
Multiple Reassortants of H5N8 Clade 2.3.4.4b Highly Pathogenic Avian Influenza Viruses Detected in South Korea during the Winter of 2020–2021
title Multiple Reassortants of H5N8 Clade 2.3.4.4b Highly Pathogenic Avian Influenza Viruses Detected in South Korea during the Winter of 2020–2021
title_full Multiple Reassortants of H5N8 Clade 2.3.4.4b Highly Pathogenic Avian Influenza Viruses Detected in South Korea during the Winter of 2020–2021
title_fullStr Multiple Reassortants of H5N8 Clade 2.3.4.4b Highly Pathogenic Avian Influenza Viruses Detected in South Korea during the Winter of 2020–2021
title_full_unstemmed Multiple Reassortants of H5N8 Clade 2.3.4.4b Highly Pathogenic Avian Influenza Viruses Detected in South Korea during the Winter of 2020–2021
title_short Multiple Reassortants of H5N8 Clade 2.3.4.4b Highly Pathogenic Avian Influenza Viruses Detected in South Korea during the Winter of 2020–2021
title_sort multiple reassortants of h5n8 clade 2.3.4.4b highly pathogenic avian influenza viruses detected in south korea during the winter of 2020–2021
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001867/
https://www.ncbi.nlm.nih.gov/pubmed/33809549
http://dx.doi.org/10.3390/v13030490
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