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Percutaneous Two-Dimensional Shear Wave Elastography for Diagnosis of Pancreatic Tumor

Background: To investigate the efficacy of two-dimensional shear wave elastography (2D-SWE) for the diagnosis of pancreatic mass lesions. Methods: This ethics committee–approved cross-sectional study included 52 patients with histologically-proven pancreatic tumors (pancreatic ductal adenocarcinoma...

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Detalles Bibliográficos
Autores principales: Iino, Yotaro, Maruyama, Hitoshi, Mikata, Rintaro, Yasui, Shin, Koroki, Keisuke, Nagashima, Hiroki, Awatsu, Masami, Shingyoji, Ayako, Kusakabe, Yuko, Kobayashi, Kazufumi, Kiyono, Soichiro, Nakamura, Masato, Ohyama, Hiroshi, Sugiyama, Harutoshi, Sakai, Yuji, Chiba, Tetsuhiro, Kato, Jun, Tsuyuguchi, Toshio, Kato, Naoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001884/
https://www.ncbi.nlm.nih.gov/pubmed/33799777
http://dx.doi.org/10.3390/diagnostics11030498
Descripción
Sumario:Background: To investigate the efficacy of two-dimensional shear wave elastography (2D-SWE) for the diagnosis of pancreatic mass lesions. Methods: This ethics committee–approved cross-sectional study included 52 patients with histologically-proven pancreatic tumors (pancreatic ductal adenocarcinoma (PDAC), 36; tumor-forming pancreatitis (TFP), 15; neuroendocrine tumor, 1) and 33 control subjects. The 2D-SWE was performed for the tumor/non-tumor tissues, and SWE-mapping patterns and propagation quality were assessed. Results: Three mapping patterns were detected based on the size and distribution of the coloring areas. Pattern A (whole coloring) was detected in all non-tumor tissues and TFP, whereas pattern C (multiple small coloring spots) was detected in PDAC only. Pattern B (partial coloring with smaller spots) was detected in other lesions. The specificity and positive predictive value of pattern A for non-PDAC and those of pattern C for PDAC were 100%. The SWE value was higher in tumor lesions than in the non-tumor tissues (38.1 vs. 9.8 kPa; p < 0.001) in patients with PDAC. The SWE value in the non-tumor lesion was higher in patients with PDAC than in control (9.8 vs. 7.5 kPa; p < 0.001). Conclusions: 2D-SWE may play a role as a novel diagnostic tool for PDAC to detect a specific mapping pattern with quantitative assessment.