Stroma-Mediated Resistance to S63845 and Venetoclax through MCL-1 and BCL-2 Expression Changes Induced by miR-193b-3p and miR-21-5p Dysregulation in Multiple Myeloma

BH3-mimetics targeting anti-apoptotic proteins such as MCL-1 (S63845) or BCL-2 (venetoclax) are currently being evaluated as effective therapies for the treatment of multiple myeloma (MM). Interleukin 6, produced by mesenchymal stromal cells (MSCs), has been shown to modify the expression of anti-ap...

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Detalles Bibliográficos
Autores principales: Algarín, Esperanza M., Quwaider, Dalia, Campos-Laborie, Francisco J., Díaz-Tejedor, Andrea, Mogollón, Pedro, Vuelta, Elena, Martín-Sánchez, Montserrat, San-Segundo, Laura, González-Méndez, Lorena, Gutiérrez, Norma C., García-Sanz, Ramón, Paíno, Teresa, De Las Rivas, Javier, Ocio, Enrique M., Garayoa, Mercedes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001939/
https://www.ncbi.nlm.nih.gov/pubmed/33806619
http://dx.doi.org/10.3390/cells10030559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001939/
https://www.ncbi.nlm.nih.gov/pubmed/33806619
http://dx.doi.org/10.3390/cells10030559

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